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Keywords: Notch signaling
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Journal Articles
Journal: Development
Development (2022) 149 (13): dev200083.
Published: 8 July 2022
... mesoderm at presomite stages. Functionally, we found that initial synchrony and the first ∼6-8 oscillation cycles occurred even when Notch signaling was impaired, revealing similarities to previous findings made in zebrafish embryos. Finally, we show that a spatial period gradient is present at the onset...
Includes: Supplementary data
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Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... quiescence, it remains unclear whether intrinsic and extrinsic cues coordinate to control quiescence and how cue coordination is achieved. Here, we report that Notch signaling coordinates neuroblast intrinsic temporal programs with extrinsic nutrient cues to regulate quiescence in Drosophila . When Notch...
Includes: Supplementary data
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In collection:
Neural development
Journal: Development
Development (2020) 147 (16): dev191312.
Published: 27 August 2020
... interneurons. In the differentiation of V2a and V2b cells, Notch signaling promotes V2b fate at the expense of V2a fate. Later, V2b cells extend axons along the ipsilateral side of the spinal cord and express the inhibitory transmitter GABA. Notch signaling has been reported to inhibit the axonal outgrowth...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163469.
Published: 2 July 2018
..., the putative guanine nucleotide exchange factor for Rab GTPases, is involved in restricting the apical delivery of Sanpodo to control spatiotemporal Notch activation following asymmetric cell division in Drosophila sensory organs. Asymmetric cell division Notch signaling Rab8 Stratum Guanine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
...Juan C. Luna-Escalante; Pau Formosa-Jordan; Marta Ibañes ABSTRACT During metazoan development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent cells. This occurs through either lateral inhibition, in which adjacent cells acquire distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
...Juan C. Luna-Escalante; Pau Formosa-Jordan; Marta Ibañes ABSTRACT During metazoan development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent cells. This occurs through either lateral inhibition, in which adjacent cells acquire distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3465–3474.
Published: 1 October 2017
... and adult brain differ considerably, but Notch signaling and inhibitor of DNA-binding (ID) factors are pivotal in both. Notch and ID factors regulate NSC maintenance; however, it has been difficult to evaluate how these pathways potentially interact. Here, we combined mathematical modeling with analysis...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (8): 1510–1517.
Published: 15 April 2017
... for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (8): 1510–1517.
Published: 15 April 2017
... for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (17): 3085–3096.
Published: 1 September 2016
... of Notch signaling. Although loss of Epb41l5 does not significantly alter the pattern of neural progenitor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and differentiation after neurulation when NPCs normally acquire organized apical junctional complexes (AJCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2160–2171.
Published: 15 June 2016
... pathways, were not affected but the intensity of Notch signaling was severely diminished. Although Notch1 and Notch2 receptors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely reduced. Postnatal development analysis revealed that in cilia-deficient CECs...
Includes: Supplementary data