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Keywords: Notch signaling
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Journal Articles
Journal: Development
Development (2020) 147 (17): dev185249.
Published: 11 September 2020
..., is expressed by second heart field (SHF) progenitors at time-points that are crucial in SHF biology. Dll4-mediated Notch signaling is required for maintaining an adequate pool of SHF progenitors, such that Dll4 knockout results in a reduction in proliferation and an increase in apoptosis. A reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev191312.
Published: 27 August 2020
... interneurons. In the differentiation of V2a and V2b cells, Notch signaling promotes V2b fate at the expense of V2a fate. Later, V2b cells extend axons along the ipsilateral side of the spinal cord and express the inhibitory transmitter GABA. Notch signaling has been reported to inhibit the axonal outgrowth of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
... arise from a common thymic epithelial progenitor cell (TEPC). However, the mechanisms controlling cTEC and mTEC production from the common TEPC are not understood. Here, we show that emergence of the earliest mTEC lineage-restricted progenitors requires active NOTCH signaling in progenitor TEC and that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163469.
Published: 02 July 2018
... ). An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases . Proc. Natl. Acad. Sci. USA   104 , 3312 - 3317 . 10.1073/pnas.0611511104 Bray , S. ( 1998 ). Notch signalling in Drosophila: three ways to use a pathway . Semin. Cell Dev. Biol.   9 , 591...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
...Juan C. Luna-Escalante; Pau Formosa-Jordan; Marta Ibañes ABSTRACT During metazoan development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent cells. This occurs through either lateral inhibition, in which adjacent cells acquire distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3465–3474.
Published: 01 October 2017
... and adult brain differ considerably, but Notch signaling and inhibitor of DNA-binding (ID) factors are pivotal in both. Notch and ID factors regulate NSC maintenance; however, it has been difficult to evaluate how these pathways potentially interact. Here, we combined mathematical modeling with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1510–1517.
Published: 15 April 2017
... maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3532–3539.
Published: 01 October 2016
..., we found that the Notch signaling pathway was dramatically downregulated in Brg1- deficient duodenum. Remarkably, overexpression of the Notch1 intercellular domain (ICD) partially reversed the prognosis of intestinal Brg1 mutant mice. Notch1 ICD overexpression rescued morphogenesis, prevented over...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3085–3096.
Published: 01 September 2016
... Notch signaling. Although loss of Epb41l5 does not significantly alter the pattern of neural progenitor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and differentiation after neurulation when NPCs normally acquire organized apical junctional complexes (AJCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2160–2171.
Published: 15 June 2016
... pathways, were not affected but the intensity of Notch signaling was severely diminished. Although Notch1 and Notch2 receptors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely reduced. Postnatal development analysis revealed that in cilia-deficient CECs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3009–3020.
Published: 01 September 2015
... primordium, Meis1 coordinates, in a dose-dependent manner, retinal proliferation and differentiation by regulating genes responsible for human microphthalmia and components of the Notch signaling pathway. In addition, Meis1 is required for eye patterning by controlling a set of eye territory-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2962–2971.
Published: 01 September 2015
...Lauren J. Manderfield; Haig Aghajanian; Kurt A. Engleka; Lillian Y. Lim; Feiyan Liu; Rajan Jain; Li Li; Eric N. Olson; Jonathan A. Epstein Notch signaling has well-defined roles in the assembly of arterial walls and in the development of the endothelium and smooth muscle of the vasculature. Hippo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 774–786.
Published: 15 February 2015
...Yi Zhou; Rui Ge; Rui Wang; Feng Liu; Yuefeng Huang; Heng Liu; Yan Hao; Qin Zhou; Chen Wang Angiogenesis is spatially and temporally orchestrated by a myriad of signaling pathways, including the Notch signaling pathway. Here, we identified UXT as an evolutionarily conserved and developmentally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4468–4478.
Published: 01 December 2014
... identified. Although we have recently found that constitutively activating NOTCH signaling in Sertoli cells leads to premature differentiation of all prospermatogonia and sterility, suggesting that there is a crucial role for this pathway in the testis stem cell niche, a true physiological function of NOTCH...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3243–3254.
Published: 15 August 2014
...Kate A. Maurer; Amy N. Riesenberg; Nadean L. Brown Notch signaling regulates basic helix-loop-helix (bHLH) factors as an evolutionarily conserved module, but the tissue-specific mechanisms are incompletely elucidated. In the mouse retina, bHLH genes Atoh7 and Neurog2 have distinct functions, with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2780–2790.
Published: 15 July 2014
... differentiation of muscle progenitor cells. We first show that cell cycle exit and myogenic differentiation can be uncoupled. In addition, we establish that skeletal muscle progenitor cells require Notch signaling to maintain their cycling status. Using several mouse models combined with ex vivo studies, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1671–1682.
Published: 15 April 2014
...Jun Hatakeyama; Yoshio Wakamatsu; Akira Nagafuchi; Ryoichiro Kageyama; Ryuichi Shigemoto; Kenji Shimamura The development of the vertebrate brain requires an exquisite balance between proliferation and differentiation of neural progenitors. Notch signaling plays a pivotal role in regulating this...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3777–3786.
Published: 15 September 2013
.... Furthermore, we find that Notch signaling is activated before p63 expression in ectodermal progenitor cells. Inhibition of Notch signaling pharmacologically or genetically reveals a negative regulatory role for Notch signaling in p63 expression during ectodermal specification in hESCs or mouse embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 897–905.
Published: 15 February 2013
... National Science Foundation [IOS-1052333]. Deposited in PMC for release after 12 months. References Assa-Kunik E. , Torres I. L. , Schejter E. D. , Johnston D. S. , Shilo B. Z. ( 2007 ). Drosophila follicle cells are patterned by multiple levels of Notch signaling and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 594–605.
Published: 01 February 2013
...Yujin Zhang; Oliver Lam; Minh-Thanh T. Nguyen; Gracia Ng; Warren S. Pear; Walden Ai; I-Jong Wang; Winston W.-Y. Kao; Chia-Yang Liu Conjunctival goblet cells primarily synthesize mucins to lubricate the ocular surface, which is essential for normal vision. Notch signaling has been known to associate...
Includes: Supplementary data