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Keywords: Notch
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Journal Articles
Journal: Development
Development (2021) 148 (10): dev197301.
Published: 17 May 2021
... predicts an adhesion-dominant intercalation mechanism. Genetic experiments support this prediction, revealing a role for adhesion through the Nephrin proteins Roughest and Hibris. Second, we found that cone cell intercalation is regulated by the Notch pathway. Third, we show that endocytosis is required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev189191.
Published: 17 February 2021
...Toshiyuki Ohtsuka; Ryoichiro Kageyama ABSTRACT Neural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192203.
Published: 07 October 2020
...-positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in DN4 and DP cells is oncogenic. Here, we show that pre-TCR signalling leads to increased expression of the transcriptional repressor Bcl6 and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
...Katherine Leisan Luo; Ryan S. Underwood; Iva Greenwald ABSTRACT During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev162263.
Published: 22 June 2020
... Brooker , R. , Hozumi , K. and Lewis , J. ( 2006 ). Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear . Development   133 , 1277 - 1286 . 10.1242/dev.02284 Brown , A. S. and Epstein , D. J. ( 2011 ). Otic ablation of smoothened reveals...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
... self-tolerance, but the mechanisms controlling their fetal specification and differentiation are poorly understood. Here, we show that notch signaling is required to specify and expand the mTEC lineage. Notch1 is expressed by and active in TEC progenitors. Deletion of Notch1 in TECs resulted in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev181024.
Published: 27 August 2019
... identity of the approaching secondary sprout emerging from the posterior cardinal vein. Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell behaviour and Notch signalling activity in the seemingly identical primary ISVs that is independent of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev170241.
Published: 02 August 2019
... the boundary between tendon and bone by regulating cell fate decisions through a mechanism that employs Notch signaling. Summary: FGF signaling is essential in establishing the graded transitional tissue of the tendon-bone attachment unit by regulating cell fate decisions and the development of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev170837.
Published: 24 July 2019
...Ankita Singh; Maimuna S. Paul; Debdeep Dutta; Mousumi Mutsuddi; Ashim Mukherjee ABSTRACT Notch signaling plays a pleiotropic role in a variety of cellular processes, including cell fate determination, differentiation, proliferation and apoptosis. The increasingly complex regulatory mechanisms of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev173195.
Published: 23 April 2019
... number, we analyzed the Notch signaling pathway. The Notch effectors LST-1 and SYGL-1 displayed age-related decreases in expression domains, suggesting a role for Notch signaling in germline aging. The results indicate that although sporadic defects account for the sterility of some animals, population...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev172510.
Published: 20 February 2019
... - and gata3 -dependent precursors co-expressing markers of V2b and V2s interneurons. Chemical blockage of Notch signalling causes a decrease in V2s and an increase in V2b cells. Our results are consistent with the existence of at least two types of precursor arranged in a hierarchical manner in the V2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev163618.
Published: 20 February 2019
... undifferentiated state of muscle stem (satellite) cells (MuSCs) is maintained by the canonical Notch pathway. Although three bHLH transcriptional factors, Hey1, HeyL and Hes1, are considered to be potential effectors of the Notch pathway exerting anti-myogenic effects, neither HeyL nor Hes1 inhibits myogenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 01 February 2019
...Domingos Henrique; François Schweisguth ABSTRACT Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in...
Journal Articles
Journal: Development
Development (2019) 146 (2): dev165589.
Published: 25 January 2019
... cells. The emergence of peri-arterial pdgfrb high MCs required Notch signaling. We found that pdgfrb -positive cells express notch2 in addition to notch3 , and although depletion of notch2 or notch3 failed to block MC emergence, embryos depleted of both notch2 and notch3 lost mesoderm- as well as neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166579.
Published: 27 November 2018
... sequencing, we show that proliferation in the early neonatal cochlea is correlated with a unique transcriptional response that diminishes with age. Furthermore, we find that augmenting Wnt signaling through the neonatal stages extends the window for HC induction in response to Notch signaling inhibition. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev169698.
Published: 09 November 2018
... specification in progenitors that exit the stem cell niche in the ciliary marginal zone (CMZ). The proper cell-type composition arising from those progenitors is a prerequisite for retinal function. Our findings in the teleost medaka ( Oryzias latipes ) uncover that the Notch-Atoh7 axis continuously patterns...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... in the control of initial DV polarity by promoting the development of the ventral center and by destabilizing transcriptionally active β-catenin. Notch β-catenin Dorsoventral development BMP Wnt8a Ventx Xenopus Zebrafish During the past two decades, many studies, mostly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163378.
Published: 02 July 2018
... activity. Biochemical experiments suggest that Bmp2-mediated Notch1 induction is achieved through transcriptional activation of the Notch ligand Jag1, and physical interaction of Smad1/5 with the intracellular domain of the Notch1 receptor. Thus, widespread myocardial Bmp2 and endocardial Notch signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev160127.
Published: 11 June 2018
..., proliferation and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting...
Includes: Supplementary data