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Keywords: Nodal signalling
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Journal Articles
Journal: Development
Development (2017) 144 (7): 1249–1260.
Published: 1 April 2017
... of the mouse T-box factor Eomes is controlled by a key gene-proximal enhancer-like element, with changes in chromatin accessibility influencing its activity in definitive endoderm. Eomesodermin Enhancer Capture-C Nodal signalling Definitive endoderm Reciprocal signalling cues between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3649–3660.
Published: 1 November 2015
... NOTCH activation results in misregulation of NODAL signalling, a major determinant of early embryonic patterning. Our study reveals a previously unidentified role for canonical NOTCH signalling during mammalian gastrulation. It also exemplifies how in vivo studies can shed light on the mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1521–1530.
Published: 15 April 2011
... proliferation along the A-P axis of the mouse embryo. Rather, we have identified that as AVE movements are being initiated, the epiblast proliferates at a much higher rate than the visceral endoderm. We show that these high levels of proliferation in the epiblast are dependent on Nodal signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1127–1135.
Published: 1 April 2010
...Steven A. Harvey; Stefan Tümpel; Julien Dubrulle; Alexander F. Schier; James C. Smith During early zebrafish development the nodal signalling pathway patterns the embryo into three germ layers, in part by inducing the expression of no tail ( ntl ), which is essential for correct mesoderm formation...
Journal Articles
Journal: Development
Development (2009) 136 (9): 1549–1557.
Published: 1 May 2009
... and axonal projections. The elaboration of habenular asymmetries requires the presence of a second asymmetric structure, the parapineal, the laterality of which is biased by unilateral Nodal signalling. Here we show that neurons are present earlier in the left habenula than in the right, but,in contrast...
Journal Articles
Journal: Development
Development (2006) 133 (18): 3709–3722.
Published: 15 September 2006
... anterior endoderm and axial mesoderm. Following mesendoderm induction, Hex is expressed in the anterior endoderm where it antagonises the propagation of the Nodal signal to prevent mesoderm formation in the head field. Broken lines indicate the induction of defined domains in the mesendoderm. Fig. 8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (14): 3331–3342.
Published: 15 July 2003
... allele in temperature shift-up and shift-down experiments to answer a central question pertaining to the timing of vertebrate floor plate induction. Abrogation of Cyc/Nodal signalling in the temperature-sensitive mutant embryos at various stages indicates that the floor plate in zebrafish is induced...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4901–4914.
Published: 1 November 2002
...Morgane Poulain; Thierry Lepage Endoderm specification in zebrafish is mediated by the zygotic transcription factors Bon/Mixer, Faust/Gata5, Casanova and Sox17, whose expression is induced by Nodal signalling. Bon/Mixer and Gata5 require Casanova in order to promote endoderm formation and all three...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4501–4510.
Published: 15 November 2001
... for nodal signaling. Cell 97 , 121 -132. Guex, N. and Peitsch, M. C. ( 1997 ). SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18 , 2714 -2723. Guex, N., Diemand, A. and Peitsch, M. C. ( 1999 ). Protein modelling for all. Trends...