... location of endoderm specification, we identified the inputs that drive internalization without the confounding influences of fate specification and global morphogenic movements. We find that Nodal signaling triggers an autocrine circuit for initiating endodermal internalization. Activation of the Nodal...

... the gastrula/neurula transition as the critical period for specification and positioning of future gill slits. Thus, reduced Nodal signaling shifts the gill slits ventrally, skews the pharyngeal domains of Hh , Pax1/9 , Pax2/5/8 , Six1/2 and IrxC towards the left, and reduces Hh and Tbx1/10 expression...

.... Chen, C. and Shen, M. M. ( 2004 ). Two modes by which Lefty proteins inhibit nodal signaling. Curr. Biol. 14 , 618 -624. Chen, Y. and Schier, A. F. ( 2001 ). The zebrafish Nodal signal Squint functions as a morphogen. Nature 411 , 607 -610. Constam, D. B. and Robertson, E. J. ( 1999...

..., National Defense Medical Center, National Defense University, Neihu, Taipei, Taiwan † These authors contributed equally to this work 15 12 2007 © 2008. 2008 Nodal signaling cdx1b Digestive organ development Zebrafish The digestive system is important...

...-like-2 (Cerl-2), respectively, act in the node region to prevent the Nodal signal from crossing to the right side, whereas chick Cerberus (cCer)has an unclear function in the left-side mesoderm. In this study, we investigate the transcriptional regulation and function of cCer in left-right development...

... with these loss-of-function analyses,gain-of-function experiments in chick embryos show that exposure of node/head process mesoderm to soluble Cripto protein results in alterations in cell fates toward anterior mesendoderm, in a manner that is dependent on Nodal signaling. Taken together, our findings support...