... in nociceptive sensory neurons in Drosophila larvae. Time course analyses reveal that Form3 is cell-autonomously required to promote dendritic arbor complexity. We show that form3 is required for the maintenance of a population of stable dendritic microtubules (MTs), and mutants exhibit defects...

... Transcription factor networks Vertebrate neural tube Nociception Pain Thermosensation Pruriception Itch Mechanosensation Cutaneous Touch Proprioception National Institutes of Health 10.13039/100000002 R01 HD037932 R01 NS032817 Rita Allen Foundation 10.13039/100001447...

... reduced the overall length of dendritic arbors, increased the expression of Spir, and produced inappropriate F-actin-rich dendrites at positions too near the cell soma. Selective removal of Lola from only class IV da neurons decreased the evasive responses of larvae to nociception. The increased Spir...

..., we followed the development of two trigeminal sensory neuron subtypes: one that expresses trpa1b , a nociceptive channel important for sensing environmental chemicals; and a distinct subtype labeled by an islet1 reporter ( Isl1SS ). We found that Trpa1b and Isl1SS neurons have overall similar axon...