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Keywords: Nkx2.2
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Journal: Development
Development (2011) 138 (15): 3213–3224.
Published: 1 August 2011
...Keith R. Anderson; Ruth A. Singer; Dina A. Balderes; Laura Hernandez-Lagunas; Christopher W. Johnson; Kristin B. Artinger; Lori Sussel The homeodomain transcription factor Nkx2.2 is essential for pancreatic development and islet cell type differentiation. We have identified Tm4sf4, an L6 domain...
Includes: Supplementary data
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Journal: Development
Development (2008) 135 (12): 2151–2160.
Published: 15 June 2008
... system. In the embryonic mouse pancreas, we found Phox2b expressed briefly together with Sox10 along the epithelial-mesenchymal border at E12.5 in cells derived from the neural crest. Downregulation of Phox2b shortly thereafter was dependent upon Nkx2.2 expressed in the adjacent pancreatic epithelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 515–523.
Published: 1 February 2007
...Michelle J. Doyle; Zoe L. Loomis; Lori Sussel The homeodomain protein Nkx2.2 (Nkx2-2) is a key regulator of pancreatic islet cell specification in mice; Nkx2.2 is essential for the differentiation of all insulin-producing β-cells and of the majority of glucagon-producing α-cells, and, in its...
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Journal Articles
Journal: Development
Development (2003) 130 (26): 6599–6609.
Published: 29 December 2003
... 3US, UK 16 9 2003 © The Company of Biologists Limited 2003 2003 Stem cell Oligodendrocyte FGF2 Spinal cord Sonic hedgehog OLIG2 NKX2.2 Neural stem cells (NSC) may be defined as self-renewing cells isolated from germinal regions of the developing and adult brain...
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Journal Articles
Journal: Development
Development (2002) 129 (20): 4785–4796.
Published: 15 October 2002
... cells also express neural markers such as Nkx2.2 and Sim1 . This pattern of avian floor-plate development presents some similarities to floor-plate formation in zebrafish embryos. We also demonstrate that, although MFP and LFP have different embryonic origins in normal development, one can...
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Journal: Development
Development (2001) 128 (14): 2723–2733.
Published: 15 July 2001
... selectively express Nkx2.2 homeodomain transcription factor, raising the possibility that Nkx2.2 may directly regulate oligogliogenesis. In this study, we have examined Nkx2.2 expression in rodent glial precursors and studied the effect of a loss of Nkx2.2 on oligodendrocyte and astrocyte differentiation. We...
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Journal Articles