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1-14 of 14
Keywords: Nkx2.2
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Journal Articles
The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2
Available to PurchaseStefanie Gross, Diana C. Garofalo, Dina A. Balderes, Teresa L. Mastracci, José M. Dias, Thomas Perlmann, Johan Ericson, Lori Sussel
Journal:
Development
Development (2016) 143 (14): 2616–2628.
Published: 15 July 2016
... in the embryo and adult. We analyzed stage- and cell type-specific deletions of Nkx2.2 and its functional domains in order to characterize its role in the development and maintenance of enteroendocrine cell lineages in the mouse duodenum and colon. Although Nkx2.2 regulates enteroendocrine cell specification...
Includes: Supplementary data
Journal Articles
The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration
Available to PurchaseKeith R. Anderson, Ruth A. Singer, Dina A. Balderes, Laura Hernandez-Lagunas, Christopher W. Johnson, Kristin B. Artinger, Lori Sussel
Journal:
Development
Development (2011) 138 (15): 3213–3224.
Published: 1 August 2011
...Keith R. Anderson; Ruth A. Singer; Dina A. Balderes; Laura Hernandez-Lagunas; Christopher W. Johnson; Kristin B. Artinger; Lori Sussel The homeodomain transcription factor Nkx2.2 is essential for pancreatic development and islet cell type differentiation. We have identified Tm4sf4, an L6 domain...
Includes: Supplementary data
Journal Articles
The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance
Available to PurchaseAndreas Holz, Heike Kollmus, Jesper Ryge, Vera Niederkofler, Jose Dias, Johan Ericson, Esther T. Stoeckli, Ole Kiehn, Hans-Henning Arnold
Journal:
Development
Development (2010) 137 (24): 4249–4260.
Published: 15 December 2010
...Andreas Holz; Heike Kollmus; Jesper Ryge; Vera Niederkofler; Jose Dias; Johan Ericson; Esther T. Stoeckli; Ole Kiehn; Hans-Henning Arnold The transcription factors Nkx2.2 and Nkx2.9 have been proposed to execute partially overlapping functions in neuronal patterning of the ventral spinal cord...
Includes: Supplementary data
Journal Articles
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
Available to PurchaseMadelen Lek, José M. Dias, Ulrika Marklund, Christopher W. Uhde, Sanja Kurdija, Qiubo Lei, Lori Sussel, John L. Rubenstein, Michael P. Matise, Hans-Henning Arnold, Thomas M. Jessell, Johan Ericson
Journal:
Development
Development (2010) 137 (23): 4051–4060.
Published: 1 December 2010
.... Floor plate Shh Homeodomain Nkx2.2 Pax6 Gli Morphogen A general strategy to establish cellular diversity in developing organisms is the deployment of morphogen gradients that signal at long range from localized sources to impart positional information to surrounding cells...
Includes: Supplementary data
Journal Articles
Signals from the neural crest regulate beta-cell mass in the pancreas
Available to Purchase
Journal:
Development
Development (2008) 135 (12): 2151–2160.
Published: 15 June 2008
... system. In the embryonic mouse pancreas, we found Phox2b expressed briefly together with Sox10 along the epithelial-mesenchymal border at E12.5 in cells derived from the neural crest. Downregulation of Phox2b shortly thereafter was dependent upon Nkx2.2 expressed in the adjacent pancreatic epithelium...
Includes: Supplementary data
Journal Articles
Nkx2.2-repressor activity is sufficient to specify α-cells and a small number of β-cells in the pancreatic islet
Available to Purchase
Journal:
Development
Development (2007) 134 (3): 515–523.
Published: 1 February 2007
...Michelle J. Doyle; Zoe L. Loomis; Lori Sussel The homeodomain protein Nkx2.2 (Nkx2-2) is a key regulator of pancreatic islet cell specification in mice; Nkx2.2 is essential for the differentiation of all insulin-producing β-cells and of the majority of glucagon-producing α-cells, and, in its...
Journal Articles
Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins
Available to PurchaseOmar Abdel Samad, Marc J. Geisen, Giuliana Caronia, Isabelle Varlet, Vincenzo Zappavigna, Johan Ericson, Christo Goridis, Filippo M. Rijli
Journal:
Development
Development (2004) 131 (16): 4071–4083.
Published: 15 August 2004
...-Pbx-Prep ternary complex formation and regulation of the Phox2b enhancer activity in ventral r4. Moreover, the DV factor Nkx2.2 enhances Hox-mediated transactivation via a derepression mechanism. Finally, we show that induction of ectopic Phox2b -expressing visceral motoneurons in the chick hindbrain...
Journal Articles
FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway
Available to PurchaseSiddharthan Chandran, Hidemasa Kato, Dianne Gerreli, Alastair Compston, Clive N. Svendsen, Nicholas D. Allen
Journal:
Development
Development (2003) 130 (26): 6599–6609.
Published: 29 December 2003
... 3US, UK 16 9 2003 © The Company of Biologists Limited 2003 2003 Stem cell Oligodendrocyte FGF2 Spinal cord Sonic hedgehog OLIG2 NKX2.2 Neural stem cells (NSC) may be defined as self-renewing cells isolated from germinal regions of the developing and adult brain...
Journal Articles
Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor
Available to PurchaseRugao Liu, Jun Cai, Xuemei Hu, Min Tan, Yingchuan Qi, Michael German, John Rubenstein, Maike Sander, Mengsheng Qiu
Journal:
Development
Development (2003) 130 (25): 6221–6231.
Published: 22 December 2003
... cord Olig2 Nkx2.2 Recent molecular and genetic studies have established that oligodendrocytes originate from specific loci of the ventral neuroepithelium along the entire neuroaxis ( Noll and Miller,1993 ; Pringle and Richardson,1993 ; Timsit et al.,1995 ; Spassky et al.,1998...
Includes: Supplementary data
Journal Articles
Dual origin of the floor plate in the avian embryo
Available to Purchase
Journal:
Development
Development (2002) 129 (20): 4785–4796.
Published: 15 October 2002
... cells also express neural markers such as Nkx2.2 and Sim1 . This pattern of avian floor-plate development presents some similarities to floor-plate formation in zebrafish embryos. We also demonstrate that, although MFP and LFP have different embryonic origins in normal development, one can...
Journal Articles
Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation
Available to PurchaseHui Fu, Yingchuan Qi, Min Tan, Jun Cai, Hirohide Takebayashi, Masato Nakafuku, William Richardson, Mengsheng Qiu
Journal:
Development
Development (2002) 129 (3): 681–693.
Published: 1 February 2002
...Hui Fu; Yingchuan Qi; Min Tan; Jun Cai; Hirohide Takebayashi; Masato Nakafuku; William Richardson; Mengsheng Qiu In this study, we have investigated the relationship of Olig2 + and Nkx2.2+ oligodendrocyte progenitors (OLPs) by comparing the expression of Olig2 and Nkx2.2 in embryonic chicken...
Journal Articles
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
Available to PurchaseYingchuan Qi, Jun Cai, Yuanyuan Wu, Rui Wu, Jeffrey Lee, Hui Fu, Mahendra Rao, Lori Sussel, John Rubenstein, Mengsheng Qiu
Journal:
Development
Development (2001) 128 (14): 2723–2733.
Published: 15 July 2001
... selectively express Nkx2.2 homeodomain transcription factor, raising the possibility that Nkx2.2 may directly regulate oligogliogenesis. In this study, we have examined Nkx2.2 expression in rodent glial precursors and studied the effect of a loss of Nkx2.2 on oligodendrocyte and astrocyte differentiation. We...
Journal Articles
Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism
Available to Purchase
Journal:
Development
Development (2001) 128 (8): 1369–1379.
Published: 15 April 2001
.... Analysis of the spatial restriction of oligodendrocyte progenitors, evidenced by their expression of O4 or PDGFRμ, indicate that they always lie within the most ventral Nkx2.2-expressing domain of the neuroepithelium, and not in the adjacent domain characterized by Pax6 expression from which somatic...
Journal Articles
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells
Available to PurchaseL. Sussel, J. Kalamaras, D. J. Hartigan-O’Connor, J. J. Meneses, R. A. Pedersen, J. L. R. Rubenstein, M. S. German
Journal:
Development
Development (1998) 125 (12): 2213–2221.
Published: 15 June 1998
... studies indicate that islet development depends on the function of an integrated network of transcription factors, the specific roles of these factors in early cell-type specification and differentiation remain elusive. Nkx2.2 is a member of the mammalian NK2 homeobox transcription factor family...