... in the embryo and adult. We analyzed stage- and cell type-specific deletions of Nkx2.2 and its functional domains in order to characterize its role in the development and maintenance of enteroendocrine cell lineages in the mouse duodenum and colon. Although Nkx2.2 regulates enteroendocrine cell specification...

...Keith R. Anderson; Ruth A. Singer; Dina A. Balderes; Laura Hernandez-Lagunas; Christopher W. Johnson; Kristin B. Artinger; Lori Sussel The homeodomain transcription factor Nkx2.2 is essential for pancreatic development and islet cell type differentiation. We have identified Tm4sf4, an L6 domain...

...Andreas Holz; Heike Kollmus; Jesper Ryge; Vera Niederkofler; Jose Dias; Johan Ericson; Esther T. Stoeckli; Ole Kiehn; Hans-Henning Arnold The transcription factors Nkx2.2 and Nkx2.9 have been proposed to execute partially overlapping functions in neuronal patterning of the ventral spinal cord...

.... Floor plate Shh Homeodomain Nkx2.2 Pax6 Gli Morphogen A general strategy to establish cellular diversity in developing organisms is the deployment of morphogen gradients that signal at long range from localized sources to impart positional information to surrounding cells...

... system. In the embryonic mouse pancreas, we found Phox2b expressed briefly together with Sox10 along the epithelial-mesenchymal border at E12.5 in cells derived from the neural crest. Downregulation of Phox2b shortly thereafter was dependent upon Nkx2.2 expressed in the adjacent pancreatic epithelium...

...Michelle J. Doyle; Zoe L. Loomis; Lori Sussel The homeodomain protein Nkx2.2 (Nkx2-2) is a key regulator of pancreatic islet cell specification in mice; Nkx2.2 is essential for the differentiation of all insulin-producing β-cells and of the majority of glucagon-producing α-cells, and, in its...

...-Pbx-Prep ternary complex formation and regulation of the Phox2b enhancer activity in ventral r4. Moreover, the DV factor Nkx2.2 enhances Hox-mediated transactivation via a derepression mechanism. Finally, we show that induction of ectopic Phox2b -expressing visceral motoneurons in the chick hindbrain...

... 3US, UK 16 9 2003 © The Company of Biologists Limited 2003 2003 Stem cell Oligodendrocyte FGF2 Spinal cord Sonic hedgehog OLIG2 NKX2.2 Neural stem cells (NSC) may be defined as self-renewing cells isolated from germinal regions of the developing and adult brain...

... cord Olig2 Nkx2.2 Recent molecular and genetic studies have established that oligodendrocytes originate from specific loci of the ventral neuroepithelium along the entire neuroaxis ( Noll and Miller,1993 ; Pringle and Richardson,1993 ; Timsit et al.,1995 ; Spassky et al.,1998...

... cells also express neural markers such as Nkx2.2 and Sim1 . This pattern of avian floor-plate development presents some similarities to floor-plate formation in zebrafish embryos. We also demonstrate that, although MFP and LFP have different embryonic origins in normal development, one can...

...Hui Fu; Yingchuan Qi; Min Tan; Jun Cai; Hirohide Takebayashi; Masato Nakafuku; William Richardson; Mengsheng Qiu In this study, we have investigated the relationship of Olig2 + and Nkx2.2+ oligodendrocyte progenitors (OLPs) by comparing the expression of Olig2 and Nkx2.2 in embryonic chicken...

... selectively express Nkx2.2 homeodomain transcription factor, raising the possibility that Nkx2.2 may directly regulate oligogliogenesis. In this study, we have examined Nkx2.2 expression in rodent glial precursors and studied the effect of a loss of Nkx2.2 on oligodendrocyte and astrocyte differentiation. We...

.... Analysis of the spatial restriction of oligodendrocyte progenitors, evidenced by their expression of O4 or PDGFRμ, indicate that they always lie within the most ventral Nkx2.2-expressing domain of the neuroepithelium, and not in the adjacent domain characterized by Pax6 expression from which somatic...

... studies indicate that islet development depends on the function of an integrated network of transcription factors, the specific roles of these factors in early cell-type specification and differentiation remain elusive. Nkx2.2 is a member of the mammalian NK2 homeobox transcription factor family...