... are first zygotically expressed at the mid-blastula transition, in the dorsal-vegetal region including the Nieuwkoop center. Xnr5 and Xnr6 were isolated by expression screening of a library enriched with immediate-early-type transcripts, and are strong inducers of both mesoderm and endoderm. They also...

... and wnt8b share a common activity but are involved in distinct developmental pathways . Development 121 , 1787 – 1799 . 10.1242/dev.121.6.1787 Koos , D. S. and Ho , R. K. (1998). The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish...

... primitive streak. * Author for correspondence (e-mail: [email protected]) 18 3 1999 4 5 1999 © 1999 by Company of Biologists 1999 Cardiac mesoderm Chick embryos Gastrulation Gene expression Heart In situ hybridization Neurulation Nieuwkoop center Regionalization...

[email protected]) 3 March 1998 28 December 1998 © 1999 by Company of Biologists 1999 Spemann organizer Nieuwkoop center Notochord Prechordal mesendoderm Dorsal forerunner cells A-P patterning bozozok Axis A series of inductive events establishes the vertebrate...

... the reconstituted Hensen’s node and, therefore, acts like a Nieuwkoop Center. These findings increase our understanding of the mechanism of notochord reconstitution, provide new information and a novel model system for studying the induction of the organizer and reveal the potential of the epiblast to regulate its...

[email protected]) 22 09 1997 © 1997 by Company of Biologists 1997 twin goosecoid siamois Xenopus homeobox Wnt cortical rotation Spemann’s organizer Nieuwkoop Center dorsal determinants LEF1 TCF3 gastrulation Discovery of the amphibian organizer played a central role...

... dorsoposterior side of the embryo. On arrival at their destination, the activated determinants form, in all chordates, an induction center homologous to the amphibian ‘Nieuwkoop center’, which induces the formation of ‘Spemann’s organizer’. On the basis of the above general scenario, a revision is proposed...

... insight into the activity of the dorsalizing region, called the Nieuwkoop Center. (1) The activity of this dorsalizing center involves an entire signal transduction pathway that requires maternal β-catenin (Heasman, J., Crawford, A., Goldstone, K., Garner-Hamrick, P., Gumbiner, B., McCrea, P., Kintner, C...