1-3 of 3
Keywords: Niemann-Pick Type C
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

The role of Niemann–Pick type C2 in zebrafish embryonic development

Wei-Chia Tseng, Ana J. Johnson Escauriza, Chon-Hwa Tsai-Morris, Benjamin Feldman, Ryan K. Dale, Christopher A. Wassif, Forbes D. Porter
Journal: Development
Development (2021) 148 (7): dev194258.
DOI: https://doi.org/10.1242/dev.194258
Published: 15 April 2021
... zebrafish to uncover the role of Npc2 and intracellular cholesterol trafficking during embryonic development. Zebrafish Niemann–Pick type C Niemann–Pick type C2 Npc2 Notch3 Cholesterol Intracellular cholesterol trafficking starts with low-density lipoproteins (LDL) entering cells via...
View article
PDF
Includes: Supplementary data
Journal Articles

Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease

Xun Huang, James T. Warren, JoAnn Buchanan, Lawrence I. Gilbert, Matthew P. Scott
Journal: Development
Development (2007) 134 (20): 3733–3742.
DOI: https://doi.org/10.1242/dev.004572
Published: 15 October 2007
...Xun Huang; James T. Warren; JoAnn Buchanan; Lawrence I. Gilbert; Matthew P. Scott Mutations in either of the two human Niemann-Pick type C (NPC) genes, NPC1 and NPC2 , cause a fatal neurodegenerative disease associated with abnormal cholesterol accumulation in cells. npc1a ,the Drosophila NPC1...
View article
PDF
Journal Articles

A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis

Xun Huang, Kaye Suyama, JoAnn Buchanan, Alan J. Zhu, Matthew P. Scott
Journal: Development
Development (2005) 132 (22): 5115–5124.
DOI: https://doi.org/10.1242/dev.02079
Published: 15 November 2005
...Xun Huang; Kaye Suyama; JoAnn Buchanan; Alan J. Zhu; Matthew P. Scott Niemann-Pick type C (NPC) disease is a fatal autosomal-recessive neurodegenerative disorder characterized by the inappropriate accumulation of unesterified cholesterol in aberrant organelles. The disease is due to mutations...
View article
PDF