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Keywords: Niche
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev199890.
Published: 4 February 2022
...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200093.
Published: 2 December 2021
... to coordination of development by robust regulation of the proportions and position of the cells and tissues within the embryo, which is crucial for functional germ cell maturation. Such tissue co-development provides a dynamic, contextual niche for PGC development. We argue that there is evidence for a clear...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193458.
Published: 18 January 2021
.... et al. ( 2017 ). Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis . Sci. Transl. Med. 9 , eaai8710 . 10.1126/scitranslmed.aai8710 Cau , F. , Pisu , E. , Gerosa , C. , Senes , G. , Ronchi , F. , Botta , C...
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. upd continues to be produced by niche cells in the adult testis but declines with age ( Kiger et al., 2001 ; Toledano et al., 2012 ; Tulina and Matunis, 2001...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 5 December 2018
...Rebecca P. Kim-Yip; Todd G. Nystul ABSTRACT Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (23): dev164285.
Published: 4 December 2018
...Renee D. Read ABSTRACT Stem cells reside in specialized microenvironments, called niches, that regulate their development and the development of their progeny. However, the development and maintenance of niches are poorly understood. In the Drosophila brain, cortex glial cells provide a niche...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev162115.
Published: 21 September 2018
...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 1 August 2018
... and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev159186.
Published: 5 April 2018
... mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev139691.
Published: 22 January 2018
...Xin Gao; Chunliang Xu; Noboru Asada; Paul S. Frenette ABSTRACT Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 998–1007.
Published: 15 March 2017
... organ from which they derive, including the formation of a stem cell niche. This has facilitated the systematic experimental manipulation and single-cell, high-throughput imaging of stem cells within their respective niches. Furthermore, emerging technologies now make it possible to engineer organoids...
Journal Articles
Journal: Development
Development (2017) 144 (5): 820–829.
Published: 1 March 2017
...Susan E. Doyle; Matthew C. Pahl; Karsten H. Siller; Lindsay Ardiff; Sarah E. Siegrist Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 1 December 2016
.../ Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary. CHK2 Differentiation Germline stem cell Lok Niche Self-renewal Stem cells in adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2877–2881.
Published: 15 August 2016
...Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic...
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 1 March 2016
... Testis Niche The phenotypic difference between males and females, or sexual dimorphism, arises from a variety of genetic or environmental mechanisms across animal species. In many organisms, male versus female cell fate decisions established during development were thought to be unalterable...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4242–4252.
Published: 15 December 2015
... in which to study both stem cell self-renewal and lineage differentiation at the molecular and cellular level. Recently, we have proposed that escort cells (ECs) form a differentiation niche to control GSC lineage specification extrinsically. However, it remains poorly understood how the maintenance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 1 March 2015
...Tamar Lengil; Dana Gancz; Lilach Gilboa How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3441–3444.
Published: 15 September 2014
...Kateri Moore; Giulio Cossu In May 2014, approximately 200 stem cell scientists from all over world gathered near Copenhagen in Denmark to participate in ‘The Stem Cell Niche’, part of the Copenhagen Bioscience Conferences series. The meeting covered an array of different stem cell systems from...