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Keywords: Niche
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Journal Articles
Journal: Development
Development (2023) 150 (16): dev201640.
Published: 17 August 2023
...Daniel C. McIntyre; Jeremy Nance ABSTRACT Stem cell quiescence, proliferation and differentiation are controlled by interactions with niche cells and a specialized extracellular matrix called basement membrane (BM). Direct interactions with adjacent BM are known to regulate stem cell quiescence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (8): dev201510.
Published: 27 April 2023
... that drive tissue repair and, in some cases, the development of specific cell types. Although macrophages display directed orchestration of stem cell activities, bidirectional cellular crosstalk mechanisms allow stem cells to regulate macrophage behaviour within their niche, thus increasing the complexity...
Journal Articles
Journal: Development
Development (2023) 150 (2): dev201148.
Published: 20 January 2023
...Phylis Hétié; Margaret de Cuevas; Erika L. Matunis ABSTRACT The adult Drosophila testis contains a well-defined niche created by a cluster of hub cells, which secrete signals that maintain adjacent germline stem cells and somatic cyst stem cells (CySCs). Hub cells are normally quiescent in adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev199890.
Published: 4 February 2022
...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200093.
Published: 2 December 2021
... to coordination of development by robust regulation of the proportions and position of the cells and tissues within the embryo, which is crucial for functional germ cell maturation. Such tissue co-development provides a dynamic, contextual niche for PGC development. We argue that there is evidence for a clear...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193458.
Published: 18 January 2021
... gained significant knowledge of the mechanisms that regulate lung homeostatic maintenance and regeneration. Various lung stem cell populations and their niche cells have been identified, and many studies have characterized the regulated interactions that occur between stem cells and their niche cells...
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... et al., 2009 ; Smith et al., 1988 ). LIF promotes ESC proliferation and inhibits ESC differentiation ( Ying and Smith, 2017 ), similar to the roles of Stat92E in stem cells in the Drosophila testis. Overall, this body of work demonstrates that JAK/STAT ligands from a dedicated stem cell niche...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 5 December 2018
...Rebecca P. Kim-Yip; Todd G. Nystul ABSTRACT Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (23): dev164285.
Published: 4 December 2018
...Renee D. Read ABSTRACT Stem cells reside in specialized microenvironments, called niches, that regulate their development and the development of their progeny. However, the development and maintenance of niches are poorly understood. In the Drosophila brain, cortex glial cells provide a niche...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 1 August 2018
... and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss...
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (2): dev139691.
Published: 22 January 2018
...Xin Gao; Chunliang Xu; Noboru Asada; Paul S. Frenette ABSTRACT Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 998–1007.
Published: 15 March 2017
... organ from which they derive, including the formation of a stem cell niche. This has facilitated the systematic experimental manipulation and single-cell, high-throughput imaging of stem cells within their respective niches. Furthermore, emerging technologies now make it possible to engineer organoids...
Journal Articles
Journal: Development
Development (2017) 144 (5): 820–829.
Published: 1 March 2017
...Susan E. Doyle; Matthew C. Pahl; Karsten H. Siller; Lindsay Ardiff; Sarah E. Siegrist Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 1 December 2016
... Chen , S. , Wang , S. and Xie , T. ( 2011 ). Restricting self-renewal signals within the stem cell niche: multiple levels of control . Curr. Opin. Genet. Dev.   21 , 684 - 689 . 10.1016/j.gde.2011.07.008 Clarke , M. F. and Fuller , M. ( 2006 ). Stem cells and cancer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2877–2881.
Published: 15 August 2016
...Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic...
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 1 March 2016
...: a versatile tool for Drosophila developmental studies . Genetics   175 , 1505 - 1531 . 10.1534/genetics.106.065961 de Cuevas , M. and Matunis , E. L. ( 2011 ). The stem cell niche: lessons from the Drosophila testis . Development   138 , 2861 - 2869 . 10.1242/dev.056242 Decotto...
Includes: Supplementary data