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Keywords: Niche
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Journal Articles
Journal: Development
Development (2021) 148 (2): dev193458.
Published: 18 January 2021
... epithelial stem cells. Alveolar regeneration Intermediate cell state Niche Stem cells The essential function of the lungs is to exchange oxygen in the air with carbon dioxide in the blood. At the same time, this exposure means that the lungs are vulnerable and constantly exposed to insults...
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... Biologists Ltd 2019 Summary: This Primer reviews the role of JAK/STAT signaling in stem cells and regeneration in Drosophila testis, intestine and appendages, and discusses the similarities between Drosophila and vertebrates. Drosophila Niche Germline stem cells Somatic stem cells...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 05 December 2018
...Rebecca P. Kim-Yip; Todd G. Nystul ABSTRACT Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev164285.
Published: 04 December 2018
...Renee D. Read ABSTRACT Stem cells reside in specialized microenvironments, called niches, that regulate their development and the development of their progeny. However, the development and maintenance of niches are poorly understood. In the Drosophila brain, cortex glial cells provide a niche that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev162115.
Published: 21 September 2018
...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 01 August 2018
... hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev159186.
Published: 05 April 2018
... mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition to the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev139691.
Published: 22 January 2018
...Xin Gao; Chunliang Xu; Noboru Asada; Paul S. Frenette ABSTRACT Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However, the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 998–1007.
Published: 15 March 2017
... organ from which they derive, including the formation of a stem cell niche. This has facilitated the systematic experimental manipulation and single-cell, high-throughput imaging of stem cells within their respective niches. Furthermore, emerging technologies now make it possible to engineer organoids...
Journal Articles
Journal: Development
Development (2017) 144 (5): 820–829.
Published: 01 March 2017
...Susan E. Doyle; Matthew C. Pahl; Karsten H. Siller; Lindsay Ardiff; Sarah E. Siegrist Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 01 December 2016
... , S. and Xie , T. ( 2011 ). Restricting self-renewal signals within the stem cell niche: multiple levels of control . Curr. Opin. Genet. Dev.   21 , 684 - 689 . 10.1016/j.gde.2011.07.008 Clarke , M. F. and Fuller , M. ( 2006 ). Stem cells and cancer: two faces of eve...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2877–2881.
Published: 15 August 2016
...Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic and...
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 01 March 2016
...: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life. Jak-STAT signaling Ovary Sex maintenance Stem cell Testis Niche The phenotypic difference between males and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4242–4252.
Published: 15 December 2015
... which to study both stem cell self-renewal and lineage differentiation at the molecular and cellular level. Recently, we have proposed that escort cells (ECs) form a differentiation niche to control GSC lineage specification extrinsically. However, it remains poorly understood how the maintenance and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 01 March 2015
...Tamar Lengil; Dana Gancz; Lilach Gilboa How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3441–3444.
Published: 15 September 2014
...Kateri Moore; Giulio Cossu In May 2014, approximately 200 stem cell scientists from all over world gathered near Copenhagen in Denmark to participate in ‘The Stem Cell Niche’, part of the Copenhagen Bioscience Conferences series. The meeting covered an array of different stem cell systems from...
Journal Articles
Journal: Development
Development (2014) 141 (13): 2602–2610.
Published: 01 July 2014
... contact germ cells, and that Woc is required for a Stat92E-mediated upregulation of zfh1 transcription. Our results further demonstrate that overexpression of Zfh1 in ECs can rescue GSC differentiation in woc -deficient ovaries. Thus, Zfh1 is a major Woc target in ECs. Stat signalling in niche cells has...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4490–4498.
Published: 15 November 2013
...Pankaj Sahai-Hernandez; Todd G. Nystul Epithelial stem cells are maintained within niches that promote self-renewal by providing signals that specify the stem cell fate. In the Drosophila ovary, epithelial follicle stem cells (FSCs) reside in niches at the anterior tip of the tissue and support...
Includes: Supplementary data