...Daniel C. McIntyre; Jeremy Nance ABSTRACT Stem cell quiescence, proliferation and differentiation are controlled by interactions with niche cells and a specialized extracellular matrix called basement membrane (BM). Direct interactions with adjacent BM are known to regulate stem cell quiescence...

... that drive tissue repair and, in some cases, the development of specific cell types. Although macrophages display directed orchestration of stem cell activities, bidirectional cellular crosstalk mechanisms allow stem cells to regulate macrophage behaviour within their niche, thus increasing the complexity...

...Phylis Hétié; Margaret de Cuevas; Erika L. Matunis ABSTRACT The adult Drosophila testis contains a well-defined niche created by a cluster of hub cells, which secrete signals that maintain adjacent germline stem cells and somatic cyst stem cells (CySCs). Hub cells are normally quiescent in adult...

...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...

... to coordination of development by robust regulation of the proportions and position of the cells and tissues within the embryo, which is crucial for functional germ cell maturation. Such tissue co-development provides a dynamic, contextual niche for PGC development. We argue that there is evidence for a clear...

... gained significant knowledge of the mechanisms that regulate lung homeostatic maintenance and regeneration. Various lung stem cell populations and their niche cells have been identified, and many studies have characterized the regulated interactions that occur between stem cells and their niche cells...

...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...

... et al., 2009 ; Smith et al., 1988 ). LIF promotes ESC proliferation and inhibits ESC differentiation ( Ying and Smith, 2017 ), similar to the roles of Stat92E in stem cells in the Drosophila testis. Overall, this body of work demonstrates that JAK/STAT ligands from a dedicated stem cell niche...

...Rebecca P. Kim-Yip; Todd G. Nystul ABSTRACT Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we...

...Renee D. Read ABSTRACT Stem cells reside in specialized microenvironments, called niches, that regulate their development and the development of their progeny. However, the development and maintenance of niches are poorly understood. In the Drosophila brain, cortex glial cells provide a niche...

...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...

... and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss...

... mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition...

...Xin Gao; Chunliang Xu; Noboru Asada; Paul S. Frenette ABSTRACT Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout...

...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...

... organ from which they derive, including the formation of a stem cell niche. This has facilitated the systematic experimental manipulation and single-cell, high-throughput imaging of stem cells within their respective niches. Furthermore, emerging technologies now make it possible to engineer organoids...

...Susan E. Doyle; Matthew C. Pahl; Karsten H. Siller; Lindsay Ardiff; Sarah E. Siegrist Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset...

... Chen , S. , Wang , S. and Xie , T. ( 2011 ). Restricting self-renewal signals within the stem cell niche: multiple levels of control . Curr. Opin. Genet. Dev.   21 , 684 - 689 . 10.1016/j.gde.2011.07.008 Clarke , M. F. and Fuller , M. ( 2006 ). Stem cells and cancer...

...Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic...

...: a versatile tool for Drosophila developmental studies . Genetics   175 , 1505 - 1531 . 10.1534/genetics.106.065961 de Cuevas , M. and Matunis , E. L. ( 2011 ). The stem cell niche: lessons from the Drosophila testis . Development   138 , 2861 - 2869 . 10.1242/dev.056242 Decotto...