.... Fig. 6. Rescue of OE neurogenesis in Foxg1 -/- mutants is dependent on Gdf11 gene dosage. ISH for OE neuronal lineage markers (Mash1, Ngn1 and Ncam) and sustentacular cells(Otx2), performed on horizontal sections through the OE of E16.5 wild-type and mutant littermates. Insets show high...

... in dI3 neural progenitors, with Mash1 mutants exhibiting a concordant reduction in dI3 neurons. Conversely, overexpression of Gsh2 and Mash1 leads to the ectopic production of dI3 neurons and a concomitant repression of Ngn1 expression. Our results provide evidence that genetic interactions involving...

... development using tissue-specific gene inactivation strategies are currently in progress. The Lfng -positive posteroventral otocyst is the presumptive anlage of the organ of Corti (Fekete and Wu,2002) and initially, this region is Tbx1 -negative. We show that transient wild-type expression of Ngn1...

... development MyoD Ngn1 Dorsal interneuron specification Lim homeodomain factors Neurogenesis Basic helix-loop-helix (bHLH) transcription factors are required for proper formation of the vertebrate and invertebrate nervous systems(Bertrand et al., 2002). The vertebrate neural bHLH transcription...

[email protected]) 30 1 2003 © 2003. 2003 bHLH transcription factors Transcriptional regulation Transcription repressors Chick electroporation Dorsal spinal cord development Neuronal differentiation Math1/Cath1 Mash1/Cash1 Ngn1 Ngn2 The differentiation of a proliferating neural...