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Keywords: Nf2
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Journal Articles
Journal: Development
Development (2018) 145 (9): dev162123.
Published: 30 April 2018
.... However, the mechanism of biliary tube morphogenesis in development or disease is not known. Elimination of the neurofibromatosis type 2 protein (NF2; also known as merlin or neurofibromin 2) causes hepatomegaly due to massive biliary neoductulogenesis in the mouse liver. We show that this phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3957–3967.
Published: 1 November 2017
... from the prevailing view that Rho inhibits Hippo signaling through modulating cytoskeleton remodeling and/or cell polarity. Active Rho prevents the phosphorylation of Amot Ser176, thus stabilizing the interaction between Amot and F-actin, and restricting the binding between Amot and Nf2. Moreover, Rho...
Includes: Supplementary data