... and pain transduction. Pea3 NGF Neurotrophins Sensory neurons Noxious pain Peripheral innervation Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT-2017-4597 PICT-2019-1467 PICT-2019-1472 PICT-2017-4513 Consejo Nacional de...

... and neurotrophin 3 signaling are necessary for maintenance of RUNX3 expression in PSNs. Hence, a transcriptional regulator that is crucial for specifying a generic PSN type identity after neurogenesis is later regulated by target muscle-derived signals to contribute to the specialized aspects of the sensorimotor...

..., activation of the P2X receptor signaling pathway by ATPγS or α,βMeATP inhibited BDNF-induced neurite outgrowth and branching. These findings indicate that P2X receptor signaling provides a mechanism for inhibiting neurotrophin support of SGN neurites when synaptic reorganization is occurring in the cochlea...

...Pontus C. Holm; Francisco J. Rodríguez; Adelheid Kresse; Josep M. Canals; Inmaculada Silos-Santiago; Ernest Arenas The role of glial cell-line derived neurotrophic factor (GDNF) and neurotrophins in the development of locus coeruleus noradrenergic neurons was evaluated. We found that two...

...Katharine M. Cronk; George A. Wilkinson; Rachel Grimes; Esther F. Wheeler; Sonal Jhaveri; Bengt T. Fundin; Immaculada Silos-Santiago; Lino Tessarollo; Louis F. Reichardt; Frank L. Rice This study demonstrates that innervation dependent on two different neurotrophin tyrosine kinase (trk) receptors...

... that TrkB signaling, via PI3-kinase activation, plays an important role in controlling interneuron migration in the developing cerebral cortex. *Author for correspondence (e-mail: [email protected] ) 22 3 2002 © 2002. 2002 Neurotrophins Mouse CNS/migration Interneuron While...

... dissector and volume fraction/Cavalieri methods (Kinetics Imaging). *Author for correspondence (e-mail: [email protected] ) 2 7 2001 © 2001. 2001 Artemin Sympathetic neurones Mouse Neurotrophins Artemin ( Baloh et al., 1998 ) is the most recently identified...

... a complex positive regulation that includes sites required for global expression and sites that are specifically required for DRG, trigeminal or sympathetic expression. These results provide a foundation for identification of the transcriptional machinery that specifies neurotrophin receptor expression...

... of genetic determination implicates environmental factors in this selection and specification process. We analysed, in organotypic visual cortex cultures, the specification of neurons expressing neuropeptide Y (NPY), a potent anticonvulsant. Endogenous brain-derived neurotrophic factor and neurotrophin 4/5...

...-mail: [email protected] ) 18 03 1998 30 01 1998 © 1997 by Company of Biologists 1997 taste buds sensory organ gustatation neurotrophins knockout lingual Taste buds are chemosensory organs consisting of collections of spindle-shaped modified epithelial cells...

...S. E. McKay; A. Garner; J. Caldero; R. P. Tucker; T. Large; R. W. Oppenheim ABSTRACT The neurotrophin, brain-derived neurotrophic factor, prevents motoneuron cell death during the normal development of the chick embryo. Brain-derived neurotrophic factor is a ligand for the low-affinity NGF receptor...

...Michaela Ockel; Gary R. Lewin; Yves-Alain Barde ABSTRACT The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 are structurally related proteins regulating the number of neurons in peripheral ganglia of the nervous system. Increased levels of nerve growth...

... at present address: Lab. Istologia Molecolare 2A1, DIBIT, San Raffaele, V. Olgettina 58, 20132 Milano, Italy 24 04 1995 © 1995 by Company of Biologists 1995 tyrosine kinase receptor neurotrophins alternative splicing leptomeningi sensory ganglia chick Nerve growth factor...

... effect upon BDNF mRNA at this stage ( Fig. 8 ). neurotrophins GABA A receptors c-fos Ca 2+ channels fura-2 hippocampus rat Brain-derived neurotrophic factor ( BDNF ) is a member of the neurotrophin gene family ( Barde et al., 1982 ; Leibrock et al., 1989 ), which to date...

... in vivo: cerebellar neurites generally extended only on spinal cord, sympathetic neurites on sciatic nerve, and DRG neurites on both. Neurite growth from DRG neurons has been shown to be stimulated by neurotrophins. To determine whether neurotrophins might also affect the substrate preferences of neurites...

... expression of the BDNF gene might be important in the co-ordinated development of the visual system. * Author for correspondence 16 03 1994 © 1994 by Company of Biologists 1994 neurogenesis neurotrophins optic tectum retina mRNA quantification Neurons require signals...

...Franziska Gaese; Roland Kolbeck; Yves-Alain Barde ABSTRACT The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a mono-clonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neu-rotrophin-3...

...Anna Buj-Bello; Luzia G. P. Pinon; Alun M. Davies ABSTRACT Recent work has shown that the survival of the nerve growth factor (NGF)-dependent trigeminal ganglion neurons of the mouse embryo is promoted by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) during the early stages...

...Kuo-Fen Lee; Alun M. Davies; Rudolf Jaenisch ABSTRACT To understand the role of low-affinity neurotrophin receptor p75 in neural development, we previously generated mice carrying a null mutation in the p75 locus (Lee, K. F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V...

...Vladimir L. Buchman; Alun M. Davies ABSTRACT To investigate if different neurotrophins regulate the survival of neurons at successive developmental stages, we studied the effect of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neu-rotrophin-3 (NT-3) on the survival...