... the statoacoustic ganglion (SAG) to the developing inner ear. Recombinant MIF acts as a neurotrophin in promoting both SAG directional neurite outgrowth and neuronal survival and is expressed in both the developing and mature inner ear of chick and mouse. A MIF receptor, CD74, is found on both embryonic SAG neurons...

... mice and qPCR performed in triplicate; ** P <0.01, Mann-Whitney U test). ( E ) Egr3 expression was induced ∼sixfold by NGF treatment, but not after treatment with the neurotrophins NT4 or BDNF. NGF-dependent Egr3 induction was abrogated using the MEK inhibitor U0126 (results from three...

... of purified SVZ-derived neurons, we demonstrate that the loss or inactivation of PSA on NCAM, as well as the deletion of NCAM, lead to reduced survival in response to neurotrophins including BDNF and NGF. These changes in cell survival are accompanied by an upregulation of p75 neurotrophin receptor expression...

... and their innervation were increased in the K14-noggin mice and decreased in the K14-BMP4 mice. The changes in neuron numbers and the density of innervation were not accompanied by a change in the levels of neurotrophins in the skin. These findings indicate that the normal developmental decrease in neuron numbers...

... of the C57BL/6 congenic line contained reduced numbers of follicles. RT-PCR showed that mRNA encoding TrkB and its two ligands, neurotrophin 4 (NT4) and brain-derived neurotrophic factor (BDNF), were present throughout the period of follicle formation in the mouse. In situ hybridisation showed that TrkB...

...Karin Agerman; Jens Hjerling-Leffler; Marie Pierre Blanchard; Eric Scarfone; Barbara Canlon; Christopher Nosrat; Patrik Ernfors Neurotrophins have multiple functions during peripheral nervous system development such as controlling neuronal survival, target innervation and synaptogenesis...

... Approaches to Neural Development (ed. W. M. Cowan , T. M. Jessell and S. L. Zipursky ), pp. 26 – 63 . New York : Oxford University Press . Bothwell , M. ( 1995 ). Functional interactions of neurotrophins and neurotrophin receptors . Annu. Rev. Neurosci . 18 , 223 – 253...

... neurons, embryonic nerve growth factor (NGF)-dependent nociceptive neurons switch dependency to GDNF, NTN and ART postnatally. Neurons that survive in the presence of neurotrophin 3 (NT3) or neurotrophin 4 (NT4), including proprioceptive afferents, Merkel end organs and D-hair afferents, are also...

...Valérie Castellani; Jürgen Bolz Neurotrophin-3 and its receptor TrkC are expressed during the development of the mammalian cerebral cortex. To examine whether neurotrophin-3 might play a role in the elaboration of layer-specific cortical circuits, slices of layer 6 and layers 2/3 neurons were...

...Stefan Jungbluth; Georgy Koentges; Andrew Lumsden ABSTRACT Neurotrophins signal through members of the trk family of tyrosine kinase receptors and are known to regulate several neuronal properties. Although initially characterized by their ability to prevent naturally occurring cell death...

...Luzia G. P. Piñón; Liliana Minichiello; Rüdiger Klein; Alun M. Davies ABSTRACT The sensory neurons of the embryonic mouse trigeminal ganglion are supported in culture by different neurotrophins at successive stages of development. Initially the neurons survive in response to BDNF and NT3 and later...

...Lynne M. Bianchi; Joanne C. Conover; Bernd Fritzsch; Thomas DeChiara; Ronald M. Lindsay; George D. Yancopoulos ABSTRACT The generation of mice lacking specific neurotrophins permits evaluation of the trophic requirements of particular neuronal populations throughout development. In the present...

... are required for this conversion, as the interposition of a membrane between neural tube and somites results in a failure of the dermatome to lose its epithelial arrangement. However, dermis formation can be completely rescued by coating the membranes with Neurotrophin-3, but not with the related molecule...

... low levels of p75 and trkA mRNAs in vivo. At this stage in vitro, the level of p75 mRNA is maintained and upregulated by BDNF, whereas the level of trkA mRNA is sustained independently of neurotrophins and is down regulated by BDNF. With the acquisition of NGF dependence, p75 and trkA mRNA levels...

...Georg Dechant; Stefano Biffo; Hitoshi Okazawa; Roland Kolbeck; Jutta Pottgiesser; Yves-Alain Barde ABSTRACT Previous studies using transfected cells have indicated that the mammalian receptor tyrosine kinase trk B binds the neurotrophins brain-derived neurotrophic factor, neurotrophin-3...