... of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuropilins are co-receptors that mediate signaling of kinase receptors for cytokines with crucial roles in zebrafish heart regeneration. We investigated the role of neuropilins in response to cardiac injury and heart...

... and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla...

... with high affinity to neuropilin 1 (NRP1) ( Tillo et al., 2015 ), which is expressed by both neurons and blood vessels ( Fantin et al., 2013 ). The coordinated development of neuronal and vascular networks is a prerequisite for normal nervous system architecture and function. Beginning around embryonic...

... and VEGF 189 . VEGF 165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF 121 cannot activate NRP1-dependent neuronal responses. By contrast, the role of VEGF 189 in NRP1-mediated signalling pathways has not yet...

.... , Segu L. , Buhot M.-C. , Jessell T. M. , Henderson C. E. ( 2007 ). Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development . Neuron 56 , 807 - 822 . 10.1016/j.neuron.2007.10.019 Choi Y. I. , Duke-Cohan...

...Alessandro Fantin; Quenten Schwarz; Kathryn Davidson; Eduardo M. Normando; Laura Denti; Christiana Ruhrberg Neuropilin 1 (NRP1) is a transmembrane glycoprotein that is essential for blood vessel development in vertebrates. Best known for its ability to bind members of the vascular endothelial...

... that the class 3 semaphorin SEMA3A signals through its neuropilin receptors, NRP1 and NRP2, to organise the axons that guide migrating GnRH neurons from their birthplace into the brain. By combining analysis of genetically altered mice with in vitro models, we show here that the alternative neuropilin ligand...

...Hira Lal Goel; Donggoo Bae; Bryan Pursell; Lindsey M. Gouvin; Shaolei Lu; Arthur M. Mercurio Although the neuropilins were characterized as semaphorin receptors that regulate axon guidance, they also function as vascular endothelial growth factor (VEGF) receptors and contribute to the development...

... of the metameric somites, and PNS neurons and glia differentiate from neural crest cells (NCCs) that preferentially migrate into the anterior sclerotome halves. Previous analyses of mice deficient in the class 3 semaphorin (SEMA3)receptors neuropilin (NRP) 1 or 2 raised the possibility that each controlled...

...Quenten Schwarz; Joaquim M. Vieira; Beatrice Howard; Britta J. Eickholt; Christiana Ruhrberg Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth...

... at the midpoint of the overlying somite, which is formed beneath the CaP cell body and is pioneered by the CaP axon. However, the placement of CaP cell bodies with respect to corresponding somites is poorly understood. Here, we determined the early events in CaP cell positioning using neuropilin 1a (nrp1a):gfp...

.... With these strains, the patterns of axonal projections of GC-D + neurons to necklace glomeruli can be visualized in whole mounts. We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family, Sema3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC...

... contributes to both neuronal and vascular patterning by preferentially relaying SEMA3A signals in peripheral axons and VEGF164 signals in blood vessels. * Author for correspondence (e-mail: [email protected] ) 27 2 2007 © 2007. 2007 VEGF Neuropilin Semaphorin Mouse...

.... * Author for correspondence (e-mail: [email protected] ) 8 12 2006 © 2007. 2007 Brain asymmetry Diencephalon Epithalamus Interpeduncular nucleus Axon guidance Semaphorin Neuropilin Zebrafish Development of correct connections between neurons is crucial for proper...

... and patterning are controlled by hemodynamic forces, as shown by flow manipulation and in situ hybridization with arterial markers ephrinB2 and neuropilin 1, which show that expression of both mRNAs is not genetically determined but plastic and regulated by flow. In vivo application of ephrinB2 or EphB4...

... the dorsal aorta just ventral to the notochord. Here we show that in zebrafish Sema3a1 is involved in angioblast migration in vivo. Expression of sema3a1 in somites and neuropilin 1 , which encodes for a component of the Sema3a receptor, in angioblasts suggested that Sema3a1 regulates the pathway...

... neuropilin receptors and repel sensory, sympathetic and motor axons. Here we show that CA1, CA3 and dentate gyrus axons from E15-E17 mouse embryo explants are selectively repelled by entorhinal cortex and neocortex. The secreted semaphorins Sema III and Sema IV and their receptors Neuropilin-1 and -2...