... neurones and is essential for an early stage of neurogenesis. Ablation of p27 Xic1 protein prevents differentiation of primary neurones, while overexpressing p27 Xic1 promotes their formation. p27 Xic1 may enhance neurogenesis by stabilising the bHLH protein, neurogenin. Moreover, the ability of p27 Xic1...

...N. J. Messenger; Anne E. Warner ABSTRACT Cell-type-specific antibodies have been used to follow the appearance of neurones and glia in the developing nervous system of the amphibian embryo. Differentiated neurones were recognized with antibodies against neurofilament protein while glial cells were...

...B. Chamak; A. Prochiantz ABSTRACT The influence of laminin (LN) and fibronectin (FN) on the differentiation of individual neurones from the embryonic rat central nervous system was studied in vitro . In control cultures or in the presence of soluble FN, most neurones had several dendrite-like...

...Thomas R. Van De Water ABSTRACT Statoacoustic ganglion neurones (SAG) are produced by the same group of cells (otic placode) that produce all of the receptor ceils that populate the sensory areas of the inner ear. The observation that ingrowth of SAG neurites to presumptive sensory areas...

.... The site and timing of nerve growth factor (NGF) synthesis and NGF receptor expression have been elucidated, thereby clarifying the role of this neurotrophic factor in development. A novel concept in neurotrophic factor physiology has emerged: the survival of neurones that innervate two separate target...

... experiments on factors controlling spinal cord pathway determination. * Present address: Howard Hughes Medical Institute, Columbia University, 722 West 168th Street. New York, NY 10032, USA 23 03 1988 © 1988 by Company of Biologists 1988 spinal cord glycine Xenopus neurone...

... © 1988 by Company of Biologists 1988 motoneurone neurone innervation ZPA zone of polarizing activity pattern formation positional information chick embryo limb We are interested in how motor axons reach their appropriate target muscles during development. Experiments in which...

... that govern their mutual assembly and also guide the attachments and migrations of the underlying body muscles and neurones. The first muscles and neurones may in turn express new surface molecules that refine later cell movements. Mutations in some 30 known genes disrupt the movements of cells or axons along...

... for dorsal column axons in Rana temporaria tadpoles by rotating the thoracic spinal cord through 180° from dorsal to ventral. Using HRP as a neuronal tracer we establish that many dorsal column axons from the hindlimb locate the ipsilateral or contralateral dorsal column pathway in the rotated cord. Other...