... in the formation of V1R + /apical and V2R + /basal vomeronasal sensory neurons of rodents. Single cell RNA sequencing Vomeronasal organ Notch signaling Dll4 Neuronal dichotomy Mouse Neuronal differentiation Eunice Kennedy Shriver National Institute of Child Health and Human Development http...

.... elegans Lineage Neuronal differentiation Transcriptional control The complete lineage map of every individual cell in the nematode Caenorhabditis elegans provides an excellent opportunity to study how lineage affects cellular identity ( Sulston and Horvitz, 1977 ; Sulston et al., 1983...

.... elegans touch receptor neurons by inhibiting a TEA domain-containing repressor, revealing its role in neuronal fate choice. Cell fate Neuronal differentiation Binary decision Repressors Touch receptor neurons ZEB The terminally differentiated state or cell fate of neurons distinguishes...

...-neural TF that represses dacapo . In addition to its effects on Asense and Prospero, Mnb also promotes the expression of the neuronal-specific RNA regulator Elav, strongly suggesting that Mnb facilitates neuronal differentiation. These actions of Mnb ensure the precise timing of neuronal birth, coupling...

...) in the zebrafish hindbrain. Delays in differentiation are reduced by knocking down N-cadherin, a manipulation expected to help destabilize adherens junctions (AJs). This suggested that delays in neuronal differentiation in epb41l5 -deficient embryos are related to a previously described role for Epb41l5...

... the developmental timing of this transition have not been fully elucidated, gradual elongation in the length of the cell cycle and coinciding accumulation of determinants that promote neuronal differentiation might function as a biological clock that regulates the onset of asymmetric division and neurogenesis. We...

... in Q-R,U,V. Given the expression pattern of Atoh1 and Rp58 during glutamatergic neuron differentiation, our results suggest that Rp58, which was recently identified as a potential Atoh1 direct target ( Klisch et al., 2011 ), is required downstream of Atoh1 for glutamatergic differentiation...

...Christopher Hindley; Fahad Ali; Gary McDowell; Kevin Cheng; Alison Jones; Francois Guillemot; Anna Philpott Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD , while simultaneously controlling progenitor maintenance non...

... Transcription factor Neuronal differentiation Bcl11a (CTIP1) Mouse The ability of the nervous system to integrate and relay information relies on the coordinated development of neuronal circuits. An immense diversity of neuron types is created during development. Extrinsic and intrinsic...

... that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuronal differentiation. Here, we demonstrate that Ngn2 is phosphorylated on multiple serine-proline sites in response...

... of the NOTCH intracellular domain (NICD), stimulated Delta1 expression and was required for the neuronal differentiation induced by the decrease in NOTCH signaling. Nevertheless, although Mnb/Dyrk1a GoF led to extensive withdrawal of neuronal precursors from the cell cycle, it was insufficient to elicit...

... nuclei. Similarly, maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus. These data illustrate cases where the neuronal differentiation program does not unfold...

... on retinoblast cell cycle kinetics: id2a -overexpressing retinoblasts progress from S to M phase more rapidly and they undergo mitosis more frequently, which results in macrophthalmia. Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina...

... 2009. 2009 Apoptosis Chick Delamination Msx1 Noggin Wnt1 Neural crest Neuronal differentiation Neural crest cells (NCCs) are a population of cells unique to vertebrates,which migrate from the dorsal aspect of the neural tube (NT) soon after its formation ( Le...

... of hippocampal cell fate in vitro is regulated through an interplay between the actions of BDNF and TGFβ. * Author for correspondence (e-mail: [email protected] ) 9 5 2005 ©2005. 2005 Neurogenesis Apoptosis Neuronal differentiation Hippocampus Cerebellum TGFβ2 BDNF SMAD Rat...

... in culture, the mutant mDA neurons differentiated normally. They acquired a spindle form shape and extended neurites. The mean length of their processes matched exactly that seen in the littermate controls (mixture of En1 +/– ;En2 –/– and En2 –/– )( Fig. 2D ). However, cell death was only postponed...

... to the achaete-scute/atonal class of genes( Jarman et al., 1993 ; Jan and Jan, 1994 ; Gupta and Rodrigues,1997 ). 2 10 2003 © 2004. 2004 Hydra Nematocyte Neural development Neuronal differentiation Zic odd-paired achaete-scute Nowa Zic genes form a small family of Zn-finger...

... positioning along the neurogenic cascade. During neurogenesis, cell cycle exit appears to be tightly coupled to migration to the mantle layer and to neuronal differentiation. We show that antagonizing Ebf gene activity allows the uncoupling of these processes. Ebf gene function is necessary to initiate...

... culture systems ( Kim et al.,1998 ; Kim et al.,2001 ); however, a function of Tcfap2a for NA differentiation in vivo was unknown. We demonstrate a novel requirement of Tfap2a for NA neuron differentiation in the LC. The development of the NA groups in the posterior hindbrain has not been studied...

... Neuronal differentiation Mouse To generate the diversity of vertebrate central nervous system (CNS)neurons, neuronal progenitors must receive positional information along the anteroposterior (AP) and dorsoventral (DV) axes during development. The signals that confer such positional information...