... plays a crucial role in organizing neocortical excitatory neuron circuits. Ontogenetic columns formed by clonally related neurons could be the basic structural and functional unit that constitutes the neocortex. One important issue is whether these lineage-related specific circuits also exist in other...

... of functional neuronal circuits. Further evidence that this mode of regulation might play a major role in the development of human neocortical circuits is likely to come from additional characterization of potential changes in lamination and connectivity in human neurodevelopmental disorders. In addition...