... hPSC-derived regional neural progenitors maintain their identity throughout their differentiation and exhibit differential gene expression and functions, suggesting developmental origins of astrocyte functional diversity. Human astrocyte development Astrocyte heterogeneity RNA-seq Neuron-glia...

... during Drosophila eye development. Fizzy/Cdc20 controls the early growth of the eye disc anlage and the concomitant entry of glial cells onto the disc. In contrast, fzr/cdh1 acts during neuronal patterning and photoreceptor axon growth, and subsequently affects neuron-glia interaction. To further address...

..., similar to mammalian re-myelination after injury. Drosophila Wrapping glia Neuregulin Subperineurial glia Septate junction Neuron-glia interaction Neuronal function requires the transmission of electric signals. It has long been known that glial cells insulate axons to ensure fast...

... that mediate the recognition and specific adhesion of glial and axonal membranes are largely unknown. We use the Drosophila midline of the embryonic central nervous system as a model to investigate these neuron glia interactions. During development, the midline glial cells acquire close contact to commissural...