... cord neurectoderm and presomitic mesoderm cells from neuromesodermal progenitors (NMPs). This process is orchestrated by pro-neural and pro-mesodermal transcription factors that are co-expressed in NMPs together with Hox genes, which are essential for axial allocation of NMP derivatives. NMPs reside...

...Zhi Ye; Christopher R. Braden; Andrea Wills; David Kimelman ABSTRACT During early embryogenesis, the vertebrate embryo extends from anterior to posterior because of the progressive addition of cells from a posteriorly localized neuromesodermal progenitor (NMp) population. An autoregulatory loop...

... challenging. Although the induction of cells resembling neuromesodermal progenitors (NMPs), the bona fide precursors of the spinal cord, offers a promising solution, the progressive specification of posterior MNs from these cells is not well defined. Here, we determine the signals guiding the transition...

... of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments...

...Zhi Ye; David Kimelman ABSTRACT The early vertebrate embryo extends from anterior to posterior due to the addition of neural and mesodermal cells from a neuromesodermal progenitor (NMp) population located at the most posterior end of the embryo. In order to produce mesoderm throughout this time...

...Naoyuki Tahara; Hiroko Kawakami; Katherine Q. Chen; Aaron Anderson; Malina Yamashita Peterson; Wuming Gong; Pruthvi Shah; Shinichi Hayashi; Ryuichi Nishinakamura; Yasushi Nakagawa; Daniel J. Garry; Yasuhiko Kawakami ABSTRACT Bi-potential neuromesodermal progenitors (NMPs) produce both neural...

.../ Summary: Single cell analysis of mouse PSC in vitro -derived populations, using support vector machine-based comparison with embryo-derived cells, uncovers the origin and structure of neuro-mesodermal progenitors. Neuromesodermal progenitors Single cells Transcription Cambridge...

.../user-licence-1-1/ Summary: A protocol that efficiently produces neuromesodermal progenitors from a multipotent population with progenitors for a variety of mesodermal derivatives. Embryonic stem cells Neuromesodermal progenitors Axial extension Mammalian development...

... molecular markers to identify them. Here, we elucidate the expression pattern of the transcription factor Nkx1-2 in the mouse embryo and show that it identifies axial progenitors throughout body axis elongation, including neuromesodermal progenitors and early neural and mesodermal progenitors. We create...

... the expression, regulation and function of the Myc family during mouse embryonic axis elongation and segmentation. Expression of both cMyc ( Myc – Mouse Genome Informatics) and MycN in the domains in which neuromesodermal progenitors (NMPs) and underlying caudal pre-somitic mesoderm (cPSM) cells reside...

... MPC PWPC Neuromesodermal progenitors A major shift in the view of vertebrate germ layer induction is underway, with evidence from several species indicating that germ layer induction continues after gastrulation ( Henrique et al., 2015 ; Kondoh and Takemoto, 2012 ). During body axis...

...Domingos Henrique; Elsa Abranches; Laure Verrier; Kate G. Storey Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However...

.... Epiblast stem cells Gastrulation Heterogeneity Neuromesodermal progenitors Primitive Streak Wnt signalling Mouse Lineage specification in the mouse embryo during gastrulation generates progressively more restricted precursors from initially uncommitted postimplantation epiblast...