... and represses the expression of neuronal differentiation genes. Proneural genes bHLH transcription factors Neurogenins Neocortex Neurogenesis Time is an important axis of developmental information in the neocortex; progenitor cells undergo precise temporal identity transitions that define...

...., Backus, C.,Reichardt, L. F. et al. ( 2001 ). Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J. Neurosci. 15 , 6170 -6180. Fode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M.,Goridis, C. and Guillemot, F. ( 1998 ). The bHLH protein NEUROGENIN 2...

...Liching Lo; Emma Dormand; Amy Greenwood; David J. Anderson In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 ( Ngn1 and Ngn2 ), and Mash1 are required for sensory and autonomic neurogenesis, respectively. In cultures of neural tube-derived, primitive PNS...

... from most of the striatal germinal zone. In their place, the dorsal regulators, Pax6 , neurogenin 1 and neurogenin 2 are found ectopically. Conversely, Pax6 is required to maintain the correct molecular identity of cortical progenitors. In its absence, neurogenins are lost from the cortical germinal...

...Naoko Koyano-Nakagawa; Jaesang Kim; David Anderson; Chris Kintner ABSTRACT During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal differentiation genes...