...Liqun Yuan; Shu Hu; Zeynep Okray; Xi Ren; Natalie De Geest; Annelies Claeys; Jiekun Yan; Eric Bellefroid; Bassem A. Hassan; Xiao-Jiang Quan The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity...

... expression of the proneural gene neurogenin 2 ( Ngn2 ) and prematurely depleted Bmp-expressing progenitor cells, leading to enhanced formation of Cajal-Retzius cells and complete loss of choroid plexus epithelial cells. Overexpression of Ngn2 had similar effects. These data indicate that Hes genes promote...

... contributed equally to this work 22 5 2007 © 2007. 2007 Helt Neurogenin Basic-helix-loop-helix Transcriptional repressor GABAergic neurons Glutamatergic neurons Mesencephalon Neuronal identity Transmitter phenotype determination During development, the neuronal subtype...

... 2006 © 2006. 2006 Sox10 Neural crest Fate specification Determination Dorsal root ganglion Neurogenin Zebrafish Transgene Waardenburg-Shah syndrome In the trunk and tail, sensory neurons are clustered with support cells(glia) to form a reiterated segmental series...

... neurogenin and neuroD activity. This repression of neuronal differentiation requires activation of the Notch pathway. Conversely, depletion of SRp38 activity results in a dysregulation of neurogenesis. Finally, SRp38 can interact with the peptidyltransferase center of 28S rRNA, suggesting that SRp38 activity...

.... P., Liu, M., El-Hodiri, H. M., Chu, K., Jamrich, M. and Tsai, M. J. ( 2000 ). Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol. Cell. Biol. 20 , 3292 -3307. Kadam, S. and Emerson, B. M. ( 2003 ). Transcriptional specificity of human SWI/SNF BRG1 and BRM...

... © 2003. 2003 Dorsal root ganglia Hedgehog Cyclopamine Neurogenin Neural crest Zebrafish The dorsal root ganglia (DRG) are the metamerically organized peripheral sensory ganglia important for transmitting somatosensory information from the body to the brain. The neural crest cells...

..., progenitor cells fail to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuronal precursors, and the paired homeodomain containing gene phox2a that is essential for neuronal differentiation and maintenance. Consequently, increased cell death is detected indicating...

... sensory neurons depend on different neurogenin homologs. Thus, we detected no DRG neurons in 4 dpf ngn1 MO-injected embryos. In mouse, chick and quail, there are two subsets of DRG neurons, distinguished by cell size, birth date, gene expression profile and sensory modality ( Le Douarin and Kalcheim...

... by Company of Biologists 1999 Neural crest Sensory neurogenesis Neurogenin Brn-3.0 BMP2 NT-3 Rat A fundamental question in development is how a diverse array of differentiated cell types can be produced from a multipotent population of progenitor cells. In vertebrates, this issue has...

...Sharon E. Perez; Sandra Rebelo; David J. Anderson The generation of sensory and autonomic neurons from the neural crest requires the functions of two classes of basic helix-loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively (Fode, C., Gradwohl, G., Morin, X...

... Neurogenin vertebrate neurogenesis proneural genes Sonic hedgehog zebrafish Tissues flanking the neural plate, such as the notochord and the surface ectoderm, emit signals that result in the region-specific diversification of the neuroectoderm. Subsequently, signals generated within...