... data from human fetal cortices and generated from human embryonic stem cell-derived cortical organoids (COs) to show that NEUROG1 and NEUROG2 are most highly expressed in basal neural progenitor cells, with pseudotime trajectory analyses indicating that NEUROG1 -derived lineages predominate early...

... RNA-sequencing of nascent Otx2 + cells identified the bHLH factors Ascl1 and Neurog2 as candidate regulators. CRISPR/Cas9 targeting of these factors showed that only the simultaneous loss of Ascl1 and Neurog2 prevented OTX2 expression. Our findings suggest that Ascl1 and Neurog2 act either redundantly...

...Hao Lin; Xuechen Zhu; Geng Chen; Lei Song; Li Gao; Aftab A. Khand; Ying Chen; Gufa Lin; Qinghua Tao Neurog2 is a crucial regulator of neuronal fate specification and differentiation in vivo and in vitro . However, it remains unclear how Neurog2 transactivates neuronal genes that are silenced...

...Kate A. Maurer; Amy N. Riesenberg; Nadean L. Brown Notch signaling regulates basic helix-loop-helix (bHLH) factors as an evolutionarily conserved module, but the tissue-specific mechanisms are incompletely elucidated. In the mouse retina, bHLH genes Atoh7 and Neurog2 have distinct functions...

.... During central nervous system development, the proneural gene neurogenin 2 ( Neurog2 ) contributes to many distinct neuronal types by specifying their fate and/or dictating development of their morphological features. By analyzing a mouse knock-in line expressing Cre recombinase under the control...

... horn bHLH Neuronal specification Mouse Atoh1 Neurog2 Ascl1 Formation of the neuronal network in the dorsal spinal cord requires the generation of correct numbers of neurons with specified identities. Regulation of this process starts early in nervous system development, as cells...