... provided that the original work is properly attributed. Summary: Neurogenesis redirects β-catenin from the adherens junctions to the nucleus to stimulate genes that control the growth and guidance of commissural axons in developing chick spinal cord. Spinal cord Neuroepithelium Commissural...

... using Imaris (Bitplane). For one image per individual ( n =3 at each age), CS + mitochondrial number was calculated within a 63× field of view. The region of interest was created by hand tracing a 3D surface containing only mesenchyme, only neuroectoderm or only neuroepithelium, depending on the age...

... disease and engineering of tissues for the future of regenerative medicine. Folding of epithelial tissues towards the apical surface has long been studied, but the molecular mechanisms that mediate epithelial folding towards the basal surface are just emerging. Here, we utilize zebrafish neuroepithelium...

... quiescence and are retained post-embryonically, together with neuroepithelial cells. Later in development, neuroepithelial cells undergo further cell divisions before transforming into larval neuroblasts. Our results demonstrate that the optic lobe neuroepithelium gives rise to neurons and glia over 60 h...

... and central brain, asymmetrically dividing NSCs, called neuroblasts (NBs), progress through a series of sequentially expressed transcription factors that limits self-renewal by silencing a genetic module involving the transcription factor Chinmo. Here, we find that Chinmo also promotes neuroepithelium growth...

... by The Company of Biologists Ltd 2016 Summary: This review discusses the mechanisms that generate neuronal diversity in the spinal cord, highlighting how different developmental populations produce neurons with distinct somatosensory functions. Dorsal spinal cord development Neuroepithelium...

...Michaela Wilsch-Bräuninger; Jula Peters; Judith T. M. L. Paridaen; Wieland B. Huttner Delamination of neural progenitors from the apical adherens junction belt of the neuroepithelium is a hallmark of cerebral cortex development and evolution. Specific cell biological processes preceding...

...Jennifer H. Gutzman; Hazel Sive We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens in a specific sequence, with initial...

...Yoshio Wakamatsu; Noriko Nakamura; Ju-Ahng Lee; Gregory J. Cole; Noriko Osumi Neuroepithelium is an apicobasally polarized tissue that contains neural stem cells and gives rise to neurons and glial cells of the central nervous system. The cleavage orientation of neural stem cells is thought...

... ) genes in neuroepithelial cells maintains the facial (nVII) motor neurons near the pial surface during their caudal migration in the zebrafish hindbrain. In the absence of olt/fz3a expression in the neuroepithelium, nVII motor neurons extended aberrant radial processes towards the ventricular surface...

... the wild type and the double mutant ( Fig. 6G-L and data not shown). Thus, the structural integrity of the neuroepithlium was maintained at E8.5 in Hes1;Hes5 double mutants. Fig. 6. Formation of the intercellular junctional complex at the apical side of the neuroepithelium. (A,D) Toluidine Blue...

... Cerebral cortex Cortical plate Neuroepithelium Subventricular zone Asymmetric cell division Cell migration Cell cycle Cell fate determination Layer formation Neurogenin2 Slice culture Mouse Asymmetric cell division events are important for the generation of cellular diversity...

... that pMN (brackets), which generatesPdgfra+ oligodendrocyte progenitors (OLPs), does not also generate Fgfr3+ putative astrocyte progenitors. Scale bar:50 μm. Fgfr3 Targeted deletion Astrocyte Reactive gliosis CNS Neuroepithelium In the embryonic CNS, neurones and glia develop from...

... bipotential, each capable of giving rise to either neuroretina or pigmented epithelium. The partitioning depends on extrinsic signals, notably fibroblast growth factors, which emanate from the overlying surface ectoderm and induce the adjacent neuroepithelium to assume the neuroretinal fate. Using explant...

... differentiate in oko meduzy . The ome phenotype is already expressed in the retinal neuroepithelium affecting morphology of the neuroepithelial cells. Our experiments indicate that previously unknown cell-cell interactions are involved in development of the retinal neuroepithelial sheet. In genetically mosaic...

.... No homozygous Cr1 −/− mice were born, indicating that Cr1 is necessary for embryonic development. Embryos initiated gastrulation and some embryos produced mesoderm up to day E7.5. Increasingly aberrant morphogenesis gave rise to disordered neuroepithelium that failed to produce a recognizable neural tube...

... acid binding protein (B-FABP). To determine if common mechanisms control transcription in CNS stem cells, the regulatory elements of these two genes were mapped in transgenic mice. A 257 basepair enhancer of the rat nestin gene is sufficient for expression throughout the embryonic neuroepithelium...

... system Chain migration Neural precursor Neurosphere Neuroepithelium Proliferation Immunoprecipitation Integrin The cells of the vertebrate central nervous system arise from a neuroepithelium surrounding the ventricles termed the ventricular zone (VZ; The Boulder Committee, 1970 ). During...

... and tissue growth. * Author for correspondence (e-mail: [email protected] ) 19 08 1996 © 1996 by Company of Biologists 1996 perlecan heparan sulfate proteoglycan fibroblast growth factor neuroepithelium Heparan sulfate proteoglycans (HSPGs...

... epithelium. Thus, B-FABP is expressed most likely in ensheathing cells ( Doucette, 1989 ; Pixley, 1992 ). fatty acid binding protein gene isolation radial glia ensheathing cells satellite cells neuroepithelium CNS development mouse Fatty acid binding proteins (FABPs) constitute...