...Jenaid M. Rees; Katie Kirk; Giacomo Gattoni; Dorit Hockman; Victoria A. Sleight; Dylan J. Ritter; Èlia Benito-Gutierrez; Ela W. Knapik; J. Gage Crump; Peter Fabian; J. Andrew Gillis ABSTRACT Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide...

..., a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish plvap...

... infers a neural crest origin of thyroid C cells, the major source of calcitonin in mammals and ancestors to neuroendocrine thyroid tumors. The concept is primarily based on investigations in quail–chick chimeras involving fate mapping of neural crest cells to the ultimobranchial glands that regulate Ca 2...

...-restricted progenitors in the conducting airways via Notch signaling, which is involved in the establishment of epithelial Clara, ciliated and pulmonary neuroendocrine (NE) cell populations. However, the precise molecular details of this selection process are still emerging. Our stepwise removal of the three...

...Randall S. Hewes; Dongkook Park; Sebastien A. Gauthier; Anneliese M. Schaefer; Paul H. Taghert Neuroendocrine cells are specialized to produce, maintain and release large stores of secretory peptides. We show that the Drosophila dimmed/Mist1 bHLH gene confers such a pro-secretory phenotype...

... differentiation. We describe mice that carry a targeted deletion within the Ebf2 (O/E3) gene. In Ebf2 -null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading...

... Neuroendocrine 3′ untranslated region Drosophila Fig. 1. Nos reporter transgenes for ectopic expression. (A) The nos -coding region (shaded) and 5′UTR sequences (hatched) were fused to yeast UAS sequences to permit transcriptional activation of nos by GAL4. In the UAS-nos-tub3′UTR...