... neuroectoderm of Xenopus laevis and investigated how mechanical signals regulate polarity. We reveal that the neuroectoderm is under a greater tension in the anterior-posterior direction and that perturbation of this tension causes PCP disappearance. We show that application of uniaxial stretch to explant...

... pluripotency factor Nanog in human ESCs and in mouse EpiSCs. Nanog in turn prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade,blocking progression along the endoderm lineage. This negative-feedback loop imposes stasis in neuroectoderm...

...Rolf Urbach; Dagmar Volland; Janina Seibert; Gerhard M. Technau An initial step in the development of the Drosophila central nervous system is the delamination of a stereotype population of neural stem cells (neuroblasts, NBs) from the neuroectoderm. Expression of the columnar genes ventral nervous...

... neuroectoderm. A lateral inhibition process mediated by the neurogenic genes ensures that only one cell within each proneural cluster delaminates as a neural stem cell (neuroblast). Thus, a fixed number of neuroblasts is formed, according to a stereotypical spatiotemporal and segmentally repeated pattern, each...

... and growth occurs in a number of embryonic tissues. We were interested in applying these same models to patterning and growth of the craniofacial complex. Craniofacial development Patterning Fgf Shh Neuroectoderm Facial ectoderm Neural crest Frontonasal process FNP Branchial arch...

... a crucial role to pattern the neuroectoderm along the DV axis. Dichaete is expressed in the medial and intermediate columns of the neuroectoderm, and mutant analysis indicates that Dichaete regulates cell fate and neuroblast formation in these domains. Molecular epistasis tests, double mutant analysis...

... minutes of healing. Explants and operated embryos were cultured at 15°C in plastic dishes coated with HEMA (poly(2-hydroxyethylmethacrylate)) in 0.5× MBS. Explantation of early (stage 13) neuroectoderm for luciferase assays ( Fig. 7 C) was performed in 1× Ca 2+ - and Mg 2+ -free modified Barth’s solution...

... of lateral wnt8 -expressing cells correlates with the establishment of AP brain pattern. Cell tracing experiments show that the neuroectoderm of Nodal-deficient embryos undergoes a rapid anterior-to-posterior transformation in vivo during a short period at the end of the gastrula stage. Moreover, in both...

...Christian Berger; Joachim Urban; Gerhard M. Technau One of the initial steps of neurogenesis in the Drosophila embryo is the delamination of a stereotype set of neural progenitor cells (neuroblasts) from the neuroectoderm. The time window of neuroblast segregation has been divided into five...

... . Rubenstein , J. L. R. , Shimamura , K. , Martinez , S. and Puelles , L. ( 1998 ). Regionalization of the prosencephalic neural plate . Annu. Rev. Neurosci . 21 , 445 – 477 . 10.1146/annurev.neuro.21.1.445 Takor , T. T. and Pearse , A. G. ( 1975 ). Neuroectodermal...

...Kimberly Fekany-Lee; Encina Gonzalez; Valarie Miller-Bertoglio; Lilianna Solnica-Krezel ABSTRACT The neuroectoderm of the vertebrate gastrula was proposed by Nieuwkoop to be regionalized into forebrain, midbrain, hindbrain and spinal cord by a two-step process. In the activation step, the Spemann...

... an inhibition of neural differentiation in animal caps and in whole embryos. Additionally, dnSox2 -injected cells that fail to differentiate into neural tissues are not able to adopt epidermal cell fate. These data suggest that Sox2 -class genes are essential for early neuroectoderm cells to consolidate...

... ( sog ) in ventrolateral regions of the embryo abutting the dpp domain. Here, both brk and sog antagonize the antineurogenic activity of Dpp so that only in brk sog double mutants is the neuroectoderm completely deleted. brk sog: yw brk M68 sog YS06 / FM7c ftz-lacZ sog plus four copies...

... of the functions of Snail is to repress neuroectodermal genes and restrict their expressions to the lateral regions. The derepression of the neuroectodermal genes into the ventral region in snail mutant is a possible cause of defects in gastrulation and in mesoderm differentiation. To investigate such possibility...

... at the beginning of somitogenesis. Four loci were identified that affect dorsalventral patterning of the brain, including the previously described cyclops locus. Mutant embryos of this class show a reduction of ventral neuroectodermal structures and variable fusion of the eyes. The second group includes a large...

... neuronal differentiation Xenopus neuroectoderm The development of the vertebrate CNS begins when one portion of the embryo, the ectoderm, gives rise to the neural plate rather than differentiating into epidermis. These early events in CNS development require inductive interactions between...

... to the neuroectoderm. Results of this study provide compelling evidence that the precursor population of the neural tube is contained in the distal cap epiblast of the early-primitive-streak-stage embryo. Furthermore, the regionalisation of cell fate within this small population suggest that a preliminary craniocaudal...

... conduction system desmin gene β-galactosidase heart Krox MEF2-MyoD1 myotome neuroectoderm skeletal enhancer transgenic mice Desmin is a muscle cytoskeletal protein whose gene belongs to the family of intermediate filament proteins ( Lazarides and Hubbard, 1976 ; Small and Sobieszek, 1977...