... the transition into NeuroD1-positive multipolar cells. Subsequently, repression of Prdm16 expression by NeuroD1 on the periphery of ventricular zone was crucial for appropriate progression of the multipolar phase and was required for normal cellular development. Furthermore, time-lapse imaging experiments...

... the expression of a particular bHLH factor influences RPC fate is unclear. Previously, we have shown that Neurod1 inserted into the Atoh7 locus activates the retinal ganglion cell (RGC) program in Atoh7 -expressing RPCs but not in Neurod1 -expressing RPCs, suggesting that Atoh7 -expressing RPCs are not able...

... for establishing retinal ganglion cell (RGC) fate. We analyzed the retinas of mice in which Math5 was replaced with Neurod1 or Math3 , bHLH genes that are expressed in another RPC and are required to establish amacrine cell fate. In the absence of Math5, Math5 Neurod1-KI was able to specify RGCs, activate RGC...

...-institute.org) 3 12 2007 © 2008. 2008 Cut-like Cux Spinal cord Neurogenesis Interneurons Motoneurons Neurod1 p27 Kip1 Cell cycle Mouse Neurogenesis requires the complex integration of neural progenitor proliferation, cell-cycle exit, migration and differentiation...

... marker Neurod1 , as well as reduced expression of late differentiation markers (Gαolf and Omp), suggests that neuronal differentiation in the absence of Lhx2 is primarily inhibited at, or immediate prior to, onset of OR expression. Aberrant regional expression of early and late differentiation markers...