... is known about key developmental events in this species, but also because the clock starts on the very first day of development. In this study, we identified numerous rhythmic genes in zebrafish larvae, including the key transcriptional regulators neurod and cdx1b , which are involved in neuronal...

...Christopher Hindley; Fahad Ali; Gary McDowell; Kevin Cheng; Alison Jones; Francois Guillemot; Anna Philpott Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD , while simultaneously controlling progenitor maintenance non...

... identified a novel developmental role for SRp38 in the regulation of neural differentiation. SRp38 is expressed in the neural plate during embryogenesis and is transcriptionally induced by the neurogenic bHLH protein neuroD. Overexpression of SRp38 inhibits primary neuronal differentiation at a step between...

... neuronal marker, N-tubulin , was diminished upon loss of Brg1 activity, suggesting that Brg1 is required for neuronal differentiation. The ability of the bHLH transcription factors Ngnr1 and NeuroD to drive neuronal differentiation was also abolished by loss of Brg1 function, indicating that Brg1...

... NeuroD Bmp4 Otx1 Otocyst Neurogenesis Patterning Mouse Six inner ear sensory end organs mediate balance and hearing in mammals. Three vestibular canals and associated cristae respond to angular acceleration, while the utricle and saccule with their respective macula respond to gravity...

... governing cell survival are of fundamental importance to developmental neuroscience. We report that inner ear sensory neurons are dependent on a basic helix-loop-helix transcription factor called NeuroD for survival during differentiation. Mice lacking NeuroD protein exhibit no auditory evoked potentials...

...Eric M. Morrow; Takahisa Furukawa; Jacqueline E. Lee; Constance L. Cepko ABSTRACT The expression and function of the basic helix-loop-helix (bHLH) transcription factor NeuroD were studied in the developing neural retina in rodent. neuroD was expressed in areas of undetermined retinal cells as well...

... helix-loop-helix gene, NeuroD , is expressed at the onset of neuronal differentiation. These expression patterns suggest that each gene marks a distinct stage of olfactory neuron progenitor development, in the following sequence: Mash1 > Math4C/neurogenin1 > NeuroD . We have previously reported...

...Ajay Chitnis; Chris Kintner ABSTRACT We have compared the roles of XASH-3 and NeuroD, two basic helix-loop-helix transcription factors, in the formation of primary neurons in early Xenopus embryos. When ectopically expressed in Xenopus embryos, XASH-3 and NeuroD induce ectopic primary neurons...