... through binding to a distal enhancer. Finally, overexpression of E47 in embryonic NSCs in vitro impaired neurite outgrowth, and overexpression of E47 in vivo by in utero electroporation disturbed proper layer-specific neurogenesis and upregulated p57(KIP2) expression. Overall, this study identifies E2A...

...) and by using the mouse Nogo-A exon three sequence (2361 bp), which encodes the main neurite outgrowth and cell spreading-inhibitory region of this protein. In situ hybridization was performed as previously described ( Schaeren-Wiemers and Gerfin-Moser, 1993 ). To assess the role of Nogo...

... response factor (Srf) to regulate the expression of genes encoding actin and other components of the cytoskeleton. Here, we show that MRTF-A (Mkl1) and MRTF-B (Mkl2) redundantly control neuronal migration and neurite outgrowth during mouse brain development. Conditional deletion of the genes encoding...

...+ signals in growth cones. An NCS-1 C-terminal peptide enhances only neurite branching and moderately reduces the Ca 2+ signal in growth cones compared with dsRNA knockdown. Our findings suggest that at least two separate structural domains in NCS-1 independently regulate Ca 2+ influx and neurite outgrowth...

... guidance Neurite outgrowth PI3-kinase Rac1 Calcium signaling Agrin was originally identified on the basis of its ability to induce the aggregation of acetylcholine receptors (AChRs) in muscle( Bezakova and Ruegg, 2003 ). In motoneurons, agrin is synthesized and released at the synaptic...

... hippocampal and sensory neurons. * Author for correspondence (e-mail: [email protected] ) 28 05 1999 19 07 1999 © 1999 by Company of Biologists 1999 Hippocampus Neurite outgrowth Adhesion Rat F-spondin Mindin Two of the most remarkable features of the developing...

... Semaphorin I neurite outgrowth grasshopper subgenual organ Axonal growth cones are guided to their targets during development by a wide variety of guidance cues. Generally, guidance molecules act as permissive/attractive cues, or as repulsive/inhibitory cues to effectively steer growth cones...

..., PTPζ (RPTPβ). The influence of the 6B4 proteoglycan, adsorbed onto the substratum, on cell adhesion and neurite outgrowth was studied using dissociated neurons from the cerebral cortex and thalamus. 6B4 proteoglycan adsorbed onto plastic tissue culture dishes did not support neuronal cell adhesion...

... of Biologists 1995 cell polarity chicken retina cryoculture neurite outgrowth radial glia The orientation of afferent dendrites versus efferent axons of a given neuron is crucial for directed information processing in the adult nervous system. The developmental mechanisms that guarantee...

... cell surface neurite outgrowth phosphatidylinositol-specific phospholipase C chemospecificity Cell adhesion molecules underlie the molecular mechanisms that mediate cell migration, cell-cell and cell-matrix adhesion, cytodifferentiation and synaptogenesis during development of the central...

..., without evidence of turning at this border (data not shown). These experiments demonstrate that living, but not cryostat, sections of cerebral cortex support selective attachment of and neurite outgrowth from embryonic thalamic neurons in a manner that depends upon the developmental state...

... extensive neuronal differentiation and neurite outgrowth take place. After 2 days of development, expression of the mammalian transgenes was specifically downregulated in the fish spinal cord but increased in more rostral regions of the CNS. This expression pattern was well correlated with the regulation...

... antibody (mAb). Some neurites whose outgrowth was induced by nerve growth factor (NGF) were c- kit -positive, but anti-NGF mAb did not inhibit the rmSCF-induced neurite outgrowth. rmSCF did not induce neurite outgrowth from DRGs of W / W embryos that did not express c- kit receptors on the cell surface...

... responsiveness to NCAM and N-cadherin in the developing hippocampus. NCAM-dependent neurite outgrowth from E17 neurons was largely dependent on the presence of α2–8-linked polysialic acid (PSA) on neuronal NCAM. NCAM-dependent neurite outgrowth could be fully inhibited by pertussis toxin or a combination of L...

... and tendon primordia, and not with the limb nerves. We used tenascin as a substrate for cultured neural explants and single cells in order to test for its function in neurite outgrowth. Dissociated embryonic neurons of various types attached to mixed polylysine μ enascin substrates and sprouted rapidly after...

... subunit and the membrane glycoprotein Thy-1. Both responses were found to be greatly suppressed in cultures of fibroblasts as compared to the C2 and G8-1 muscle cell lines and the C6 glioma cell line. This suppression was associated with an inhibition of NGF-dependent neuritic outgrowth from PC12 cells...