... The Netherlands CardioVascular Research Initiative Prrx1 Neuregulin Zebrafish Heart regeneration Fibrosis Fibroblasts Highlighted Article: Epicardial-expressed Prrx1 ensures a balance between the fibrotic response and myocardial regeneration post-injury in zebrafish. © 2021. Published...

... is regulated by an autocrine activation of the EGF receptor through the neuregulin homolog Vein. This resembles the molecular mechanism employed during cell-autonomous reactivation of glial differentiation after injury in mammals. We further demonstrate that Vein, produced by the wrapping glia, also regulates...

... neuregulin-like called vein ( vn ). Here, we used mutant combinations and gene replacement to determine the constraints of ligand specificity in development. Mutant analysis revealed extensive ligand redundancy in embryogenesis and wing development. Surprisingly, we found that the essential role of vn...

... that these glial cells properly associate with axons. ErbB receptors are required for Schwann cell migration, but the operative ligand and its mechanism of action have remained unknown. We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration...

... isolated three genes encoding neuregulins, ErbB3 ligands, and show that two neuregulins function together in zebrafish trunk neural crest cell migration and in DRG formation. Together,our results suggest that ErbB3 signaling is required for normal migration of trunk, but not cranial, neural crest cells...

... signals in the formation of this tissue. The differentiation of these specialized cells, unlike that of adjacent endocardial cushions and valves, is not dependent on blood flow or cardiac contraction. Finally, both neuregulin and notch1b are necessary for the development of atrioventricular conduction...

... isoform, TGFβ3, is also expressed in a target tissue of ciliary ganglion neurons. Application of TGFβ3 inhibits the functional expression of whole-cell Ca 2+ -activated K + currents evoked by 12 hour treatment with either TGFβ1 or β-neuregulin-1 in ciliary ganglion neurons developing in vitro. TGFβ3 had...

...Jeffrey A. Loeb; Tejvir S. Khurana; Janet T. Robbins; Ann G. Yee; Gerald D. Fischbach We mapped the distribution of neuregulin and its transmembrane precursor in developing, embryonic chick and mouse spinal cord. Neuregulin mRNA and protein were expressed in motor and sensory neurons shortly after...

...Jack Jiagang Zhao; Greg Lemke ABSTRACT The products of the neuregulin-1 gene constitute a set of polypeptide growth factors whose signalling through the ErbB receptors is essential to the growth and differentiation of many cell types in culture. Although studies with neuregulin-1 mutant mice have...

... ) 1 10 1997 © 1997 by Company of Biologists 1997 ErbB3 ErbB2 heregulin neuregulin cardiac development neural crest cerebellum Schwann cell stomach pancreas mouse The heregulins (HRG, neuregulins) are a family of structurally diverse glycoproteins sharing a common EGF...

... cells influence each others’ function in the developing cerebral cortex, we examined the role of glial growth factor (a soluble form of neuregulin), in neuron-radial glial interactions. Here, we show that GGF is expressed by migrating cortical neurons and promotes their migration along radial glial...