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Keywords: Neural tube defects
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (8): 1518–1530.
Published: 15 April 2017
...Olga A. Balashova; Olesya Visina; Laura N. Borodinsky Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closure during embryogenesis. The elucidation of the mechanisms underlying folate action has been challenging. This study...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
... malformations – ‘neural tube defects’ – that result when closure fails. The process of neural tube closure is complex and involves cellular events such as convergent extension, apical constriction and interkinetic nuclear migration, as well as precise molecular control via the non-canonical Wnt/planar cell...
Journal Articles
Journal: Development
Development (2015) 142 (16): 2781–2791.
Published: 15 August 2015
... development Apical constriction Brain Neural tube defects Radial glial precursor * These authors contributed equally to this work Neural tube closure defects (NTDs) are very common and severe congenital malformations that affect ∼1/1000 pregnancies ( Mitchell, 2005 ). The neural tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 3008–3017.
Published: 15 July 2013
... and reproduction in any medium provided that the original work is properly attributed. Neural tube defects Proteoglycans Wnt planar cell polarity The Wnt/PCP pathway controls a variety of cellular and developmental processes where coordinated movement and orientation of cells within the plane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3835–3845.
Published: 15 November 2010
... epithelium. We have generated Grhl2 mutant mice to demonstrate defective molecular composition of the apical junctional complex in these compartments that coincides with the occurrence of anterior and posterior neural tube defects. Mechanistically, we show that Grhl2 specifically associates with cis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (15): 2653–2663.
Published: 1 August 2009
... and embryonic survival in HAI2-deficient embryos were completely restored by the simultaneous genetic inactivation of matriptase. However, neural tube defects were detected in HAI2-deficient mice even in the absence of matriptase, although at lower frequency, indicating that the inhibition of additional serine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3203–3211.
Published: 1 September 2007
... Neurulation Morphogenesis Neural tube defects Noggin Sonic hedgehog Mouse Zic genes Neurulation is the process in which the neural plate bends and fuses to form the neural tube - the developmental forerunner of the brain and spinal cord. Understanding the molecular regulation of neurulation...
Journal Articles
Journal: Development
Development (2007) 134 (4): 789–799.
Published: 15 February 2007
... a cell-autonomous defect of convergent extension, requiring PCP signalling via RhoA-Rho kinase, during the development of severe neural tube defects in the mouse. Table 3. Frequency of open neural tubes (failure of Closure 1) among +/+, Lp /+ and Lp/Lp embryos electroporated with vectors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (16): 3957–3964.
Published: 15 August 2002
... not exhibit any obvious weakness or motor disabilities. †Author for correspondence (e-mail: robert.lazzarini@mssm.edu ) 9 4 2002 © 2002. 2002 glial cells missing Secondary neurulation Cell fate specification Neural tube defects Tail bud Mouse An Ac cI- Eco RI cDNA...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2109–2119.
Published: 1 May 2002
... Chlorate Glycosaminoglycans Heparan sulphate Neural tube defects Patched Proteoglycans Sonic hedgehog Extracellular matrix Neurulation is a fundamental morphogenetic event that culminates in the elevation, apposition and fusion of the neural folds in the dorsal midline ( Copp et al., 1990...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2581–2592.
Published: 1 July 2001
.... Natl. Acad. Sci. USA 98 , 3802 -3807. Dishevelled Wnt Convergent extension Neural tube defects Xenopus The formation of the vertebrate nervous system is a complicated developmental process that requires a tightly coordinated suite of cell-cell interactions, intracellular...
Journal Articles
Journal: Development
Development (1985) 89 (Supplement): 229–255.
Published: 1 November 1985
... will also present a new approach to testing models, based on finite element analysis, that holds promise for explaining the origin of the neural tube defects. Trinkaus summarized the state of knowledge regarding formation of the neural plate and neural tube in 1969 as follows: ' . . . the descriptive...
Journal Articles
Journal: Development
Development (1985) 88 (1): 39–54.
Published: 1 August 1985
...Andrew J. Copp The relationship between timing of closure of the posterior neuropore (PNP) and development of spinal neural tube defects (NTD) has been studied in individual mutant curly tail mouse embryos maintained in culture. Moderate delay in PNP closure results in development of tail flexion...