... double knockout (dKO) mice display neural tube defects (NTDs) coupled with reduced proliferation and precocious differentiation of NPCs. Using ribosomal protein 24 hypomorphic mice ( Rpl24 Bst/+ ) as a genetic tool to dampen global protein synthesis, we found that Lin28a −/− ;Rpl24 Bst/+ compound mutants...

...Huili Li; Jing Zhang; Lee Niswander ABSTRACT Micronutrition is essential for neural tube closure, and zinc deficiency is associated with human neural tube defects. Here, we modeled zinc deficiency in mouse embryos, and used live imaging and molecular studies to determine how zinc deficiency affects...

...Jinzhe Mao; David M. McKean; Sunita Warrier; Joshua G. Corbin; Lee Niswander; Irene E. Zohn Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further...

... ranging from Volvox to arthropods and vertebrates (e.g. Schroeder,1970 ; Sweeton et al.,1991 ; Viamontes and Kirk,1977 ). Shroom gamma-tubulin microtubule neural tube defect morphogenesis Xenopus © 2007. 2007 19 1 2007 * Author for correspondence (e...

...-fate determinants and mitotic spindle rotation during asymmetric cell division. Nat. Cell Biol. 3 , 50 -57. Botto, L. D., Moore, C. A., Khoury, M. J. and Erickson, J. D. ( 1999 ). Neural-tube defects. New Engl. J. Med. 341 , 1509 -1519. Bronner-Fraser, M. and Fraser, S. E. ( 1997...

... might improve both the fidelity and strength of transgene expression. PDGF receptor-alpha YAC transgenesis Craniofacial development Neural tube defect Lung development Oligodendrocyte Progenitor cell Three PDGF subunits (PDGF-A, -B and -C) have been identified to date. All three...

... that the orpk mutation is a hypomorphic allele of the Tg737 gene. Unlike the orpk allele, where all homozygotes survive to birth, embryos homozygous for the Tg737 Δ 2-3 α Gal mutation arrest in development at mid-gestation and exhibit neural tube defects, enlargement of the pericardial sac and, most notably...

... cells could explain the inability to effect closure. Of the two major defects in the embryonic development of vinculin null mice, the most noticeable was the failure of the neural tube to fuse in the midline, with subsequent neural tube defects (NTD) at 100% frequency. The cranial neural tubes...

... of development revealed developmental perturbations consisting of cranial neural tube defects (NTD) and heart malformations. Interestingly, breeding of the CMV43 transgene into the Cx43 knockout mice extended postnatal viability of mice homozygote for the Cx43 knockout allele, indicating that the CMV43 trangsene...