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Keywords: Neural tube
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Journal Articles
Journal: Development
Development (2021) 148 (24): dev192914.
Published: 15 December 2021
... constraints pattern and shape the mammalian embryo. Morphogenesis Mechanobiology Self-organisation Embryogenesis Organoids Somitogenesis Neural tube Stem cells Gastruloids Stembryogenesis European Molecular Biology Laboratory http://dx.doi.org/10.13039/100013060 Agence...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev197566.
Published: 25 February 2021
... the sharp boundaries that delineate these gene expression patterns arise, despite the stochasticity associated with gene regulation, is poorly understood. We show, in the vertebrate neural tube, using perturbations of coding and regulatory regions, that the structure of the regulatory network contributes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev191494.
Published: 23 December 2020
...Andrew C. Symonds; Clare E. Buckley; Charlotte A. Williams; Jonathan D. W. Clarke ABSTRACT Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
.... By investigating loss and gain of Shh function, and floor-plate deletions, we report that sclerotomal Shh is also necessary for neural tube development. Reducing the amount of Shh in the sclerotome using a membrane-tethered hedgehog-interacting protein or Patched1, but not dominant active Patched, decreased...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev176297.
Published: 04 December 2019
...Pilar Guerrero; Ruben Perez-Carrasco; Marcin Zagorski; David Page; Anna Kicheva; James Briscoe; Karen M. Page ABSTRACT Cell division, movement and differentiation contribute to pattern formation in developing tissues. This is the case in the vertebrate neural tube, in which neurons differentiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev182154.
Published: 25 November 2019
... work is properly attributed. Summary: This Review summarizes the spatial and temporal gene regulatory patterning systems that produce the diversity and organization of neurons in the vertebrate spinal cord. Gene regulatory network Hedgehog Neural tube Neurogenesis Neuronal diversity...
Journal Articles
Journal: Development
Development (2019) 146 (17): dev176784.
Published: 12 September 2019
...Atsuki Yatsuzuka; Akiko Hori; Minori Kadoya; Mami Matsuo-Takasaki; Toru Kondo; Noriaki Sasai ABSTRACT Dorsal-ventral pattern formation of the neural tube is regulated by temporal and spatial activities of extracellular signalling molecules. Sonic hedgehog (Shh) assigns ventral neural subtypes via...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173807.
Published: 27 March 2019
...Julien Delile; Teresa Rayon; Manuela Melchionda; Amelia Edwards; James Briscoe; Andreas Sagner; Allon Klein; Barbara Treutlein ABSTRACT The coordinated spatial and temporal regulation of gene expression in the vertebrate neural tube determines the identity of neural progenitors and the function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
...Evanthia Nikolopoulou; Gabriel L. Galea; Ana Rolo; Nicholas D. E. Greene; Andrew J. Copp Neural tube closure has been studied for many decades, across a range of vertebrates, as a paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the severe congenital...
Journal Articles
Journal: Development
Development (2016) 143 (12): 2183–2193.
Published: 15 June 2016
... Community Council Directive 2010/63/UE and the French Ethical Committee. Antibodies and reagents are described in Table S1 . Wild-type and mutant mouse embryos (E13.5) were collected in cold PBS and dissected in cold Hank's Balanced Salt Solution (HBSS), 6.5% glucose (Gibco). Neural tubes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1305–1314.
Published: 01 April 2015
...Joaquim Grego-Bessa; Jeffrey Hildebrand; Kathryn V. Anderson The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. The mouse neural plate is a simple epithelium that is transformed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3153–3158.
Published: 15 August 2014
... migration has not been studied in mammalian PCP mutants. Vangl2 Lp/Lp mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration and derivative formation occur normally in Vangl2 Lp/Lp embryos. The gene family member...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3423–3434.
Published: 15 August 2013
... removal of PTCH2- and PTCH1-feedback antagonism produces a significant expansion of HH-dependent ventral neural progenitors. Strikingly, complete loss of PTCH2-, HHIP1- and PTCH1-feedback inhibition results in ectopic specification of ventral cell fates throughout the neural tube, reflecting constitutive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2269–2279.
Published: 01 June 2013
... downregulation in the dorsal neural tube is thus necessary for the switch between neural and melanocytic phases of NC development. * Present address: Program in Genomics of Differentiation, National Institute of Child Health and Human Development, 6B/3B309, Bethesda, MD 20892, USA ‡ Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1467–1474.
Published: 01 April 2013
... differential gene expression. However, this view has been challenged, raising the possibility that distinct mechanisms are used to interpret different morphogens. Here, we investigate graded BMP signalling in the vertebrate neural tube. We show that defined exposure times to Bmp4 generate distinct levels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 820–830.
Published: 15 February 2013
...Mary C. McKinney; Kazumi Fukatsu; Jason Morrison; Rebecca McLennan; Marianne E. Bronner; Paul M. Kulesa Neural crest (NC) cells emerge from the dorsal trunk neural tube (NT) and migrate ventrally to colonize neuronal derivatives, as well as dorsolaterally to form melanocytes. Here, we test whether...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2416–2425.
Published: 01 July 2012
... ) Competing interests statement The authors declare no competing financial interests. 23 4 2012 © 2012. Notum Wnt Glypicans Neural tube Patterning Zebrafish Wnts are members of a family of secreted signaling molecules conserved across the animal kingdom...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1701–1711.
Published: 15 May 2012
...Heather J. Ray; Lee Niswander Tissue fusion events during embryonic development are crucial for the correct formation and function of many organs and tissues, including the heart, neural tube, eyes, face and body wall. During tissue fusion, two opposing tissue components approach one another...
Journal Articles
Journal: Development
Development (2012) 139 (2): 259–268.
Published: 15 January 2012
... axis of the neural tube. Taking advantage of chick in ovo electroporation, we show a novel role for BMP7 at the time of neurogenesis initiation in the spinal cord. Using in vivo loss-of-function experiments, we show that BMP7 activity is required for the generation of three discrete subpopulations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5429–5439.
Published: 15 December 2011
.... 19 10 2011 © 2011. Ciona Ephrin FGF Motoneurons Neural tube Notch Central pattern generators (CPGs) are discrete neuronal networks that drive rhythmic motor behaviors ( Marder and Bucher, 2001 ; Wilson and Maden, 2005 ). Spinal cord CPGs control the swimming...
Includes: Supplementary data