...Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey ABSTRACT As human pluripotent stem cells (hPSCs) exit pluripotency, they reportedly switch from glycolytic energy production to primarily mitochondrial metabolism. Here, we show that upon ectoderm differentiation to neural precursor cells (NPCs...

...Nao Morimoto-Suzki; Yusuke Hirabayashi; Kelsey Tyssowski; Jun Shinga; Miguel Vidal; Haruhiko Koseki; Yukiko Gotoh In the developing neocortex, neural precursor cells (NPCs) sequentially generate various neuronal subtypes in a defined order. Although the precise timing of the NPC fate switches...

... equally to this work Competing interests The authors declare no competing financial interests. 22 2 2013 9 12 2013 © 2014. Published by The Company of Biologists Ltd 2014 Foxa2 Nurr1 Midbrain dopamine neuron Development Neural precursor cell Epigenetic...

...Jun Lei; Marthe J. Howard Targeted deletion of the bHLH DNA-binding protein Hand2 in the neural crest, impacts development of the enteric nervous system (ENS), possibly by regulating the transition from neural precursor cell to neuron. We tested this hypothesis by targeting Hand2 deletion in nestin...

...Daichi Kawaguchi; Takeshi Yoshimatsu; Katsuto Hozumi; Yukiko Gotoh During the neurogenic phase of mammalian brain development, only a subpopulation of neural precursor cells (NPCs) differentiates into neurons. The mechanisms underlying this selection remain unclear. Here we provide evidence...

...Takeshi Yoshimatsu; Daichi Kawaguchi; Koji Oishi; Kiyoshi Takeda; Shizuo Akira; Norihisa Masuyama; Yukiko Gotoh The transcription factor STAT3 promotes astrocytic differentiation of neural precursor cells (NPCs) during postnatal development of the mouse neocortex, but little has been known...

...Yusuke Hirabayashi; Yasuhiro Itoh; Hidenori Tabata; Kazunori Nakajima; Tetsu Akiyama; Norihisa Masuyama; Yukiko Gotoh Neural precursor cells (NPCs) have the ability to self-renew and to give rise to neuronal and glial lineages. The fate decision of NPCs between proliferation and differentiation...

...Thomas Brody; Ward F. Odenwald This article considers the evidence for temporal transitions in CNS neural precursor cell gene expression during development. In Drosophila , five prospective competence states have so far been identified, characterized by the successive expression of Hb→Kr→Pdm→Cas→Gh...