...-mediated protein regulation during development. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 28 7 2008 © 2008. 2008 Sonic hedgehog Cerebellum Neural precursor Insulin-like growth factor Insulin receptor...

... and subsequently specify oligodendrocyte development. Our studies show that spatial and temporal differences in Hh signaling within a common population of neural precursors can contribute to cell fate diversification. † Author for correspondence (e mail: [email protected] ) * These authors contributed...

... process of neural precursor cell (NPC) selection by basic helix-loop-helix (bHLH) proneural transcription factors in the peripheral nervous system (PNS) by atonal related proteins (ARPs) presents an excellent model in which to address this issue. Proneural ARPs belong to two highly related groups...

... for correspondence (e-mail: [email protected] ) 30 9 2003 © 2004. 2004 Cerebellum Sonic hedgehog Proliferation GSK3 Medulloblastoma Myc Neural precursor Mouse Nmyc1 (N-myc) Developmental programs that coordinate neuronal precursor proliferation and cell cycle exit...

.... Of the Myc family members tested, only Nmyc was expressed in the proliferative zone of the cerebellum,suggesting a potential role for Nmyc in CGNP proliferation in vivo. Nmyc upregulation also occurred in proliferating neural precursor cells exposed to ectopic Shh in transgenic mice and in medulloblastomas...

...Thomas S. Jacques; João B. Relvas; Stephen Nishimura; Robert Pytela; Gwynneth M. Edwards; Charles H. Streuli; Charles ffrench-Constant* ABSTRACT Proliferation and tangential migration of neural precursor cells are essential determinants of CNS development. We have established cell culture models...

...) that give rise to neural precursors, asense is one of a number of genes that are specifically expressed in the neural precursors themselves (the neural precursor genes). We have identified a mutant asense phenotype that may reflect this later expression pattern. As a step in understanding the determination...

...Pat Simpson; Cathie Carteret The segregation of neural precursors from epidermal cells during development of the nervous system of Drosophila relies on interactions between cells that are thought to be initially equivalent. During development of the adult peripheral nervous system, failure...