... types, such as the neural plate border (NPB). Using Xenopus laevis , we set out to determine whether SoxB1 transcription factors have a regulatory function in NPB formation. Here, we show that SoxB1 factors are necessary for NPB formation, and that prolonged SoxB1 factor activity blocks the transition...

...Luciana A. Scatturice; Nicolás Vázquez; Pablo H. Strobl-Mazzulla ABSTRACT The neural plate border (NPB) of vertebrate embryos is segregated from the neural plate (NP) and epidermal regions, and comprises an intermingled group of progenitors with multiple fate potential. Recent studies have shown...

...Ankita Thawani; Helen R. Maunsell; Hongyuan Zhang; Harinarayana Ankamreddy; Andrew K. Groves ABSTRACT The Foxi3 transcription factor, expressed in the neural plate border at the end of gastrulation, is necessary for the formation of posterior placodes and is thus important for ectodermal patterning...

.... Testing the extent of a neural contribution to the pineal organ through a genetic loss-of-function approach is likely to be difficult, as any treatment that results in ablation of the neural plate (such as in Khokha et al., 2005 ) would inevitably also affect the formation of the neural plate border...

...Tomoko Watanabe; Takayoshi Yamamoto; Kohei Tsukano; Sayuki Hirano; Ayumi Horikawa; Tatsuo Michiue ABSTRACT The pre-placodal ectoderm (PPE) is a specialized ectodermal region which gives rise to the sensory organs and other systems. The PPE is induced from the neural plate border during neurulation...

...Jiejing Li; Mark Perfetto; Russell Neuner; Harinath Bahudhanapati; Laura Christian; Ketan Mathavan; Lance C. Bridges; Dominique Alfandari; Shuo Wei ABSTRACT During vertebrate gastrulation, canonical Wnt signaling induces the formation of neural plate border (NPB). Wnt is also thought to be required...

... neural crest and its subsequent migration. Neural crest Xenopus laevis embryo PFKFB 6-Phosphofructo-2-kinase/fructose-2 6-bisphosphatase AKT Migration Glycolysis Neural plate border The neural crest (NC), a migratory and multipotent cell population in vertebrate embryos, forms...

.... Mutations in the ROR2 gene cause recessive Robinow syndrome in humans, a short-limbed dwarfism associated with craniofacial malformations. Here, we show that Ror2 is required for local upregulation of gdf6 at the neural plate border in Xenopus embryos. Ror2 morphant embryos fail to upregulate neural plate...

... regulation Migration Neural crest Neural plate border Signaling Transcription factors The neural crest is a remarkable cell type, notable for its ability to migrate extensively and differentiate into numerous derivatives ( Fig. 1 A-E). An evolutionary innovation, the neural crest is thought...

...Sabine Reichert; Rebecca A. Randall; Caroline S. Hill During ectodermal patterning the neural crest and preplacodal ectoderm are specified in adjacent domains at the neural plate border. BMP signalling is required for specification of both tissues, but how it is spatially and temporally regulated...

...Stephanie Vadasz; Jonathan Marquez; Maria Tulloch; Natalia A. Shylo; Martín I. García-Castro The neural crest (NC) is a migratory population of cells unique to vertebrates that generates many diverse derivatives. NC cells arise during gastrulation at the neural plate border (NPB), which is later...

...Davalyn R. Powell; Laura Hernandez-Lagunas; Kristi LaMonica; Kristin Bruk Artinger The neural crest comprises multipotent precursor cells that are induced at the neural plate border by a series of complex signaling and genetic interactions. Several transcription factors, termed neural crest...

... prevents the ectopic expression of lateral ectoderm markers, independently of its role in neural specification. We then investigate the temporal participation of BMP/Smad signaling and suggest a later involvement in neural plate border development, likely due to widespread FGF/MAPK activity in the gastrula...

...Sunit Dutta; Igor B. Dawid Neural crest (NC) precursors are stem cells that are capable of forming many cell types after migration to different locations in the embryo. NC and placodes form at the neural plate border (NPB). The Wnt pathway is essential for specifying NC versus placodal identity...

...Cédric Patthey; Thomas Edlund; Lena Gunhaga The non-neural ectoderm is divided into neural plate border and epidermal cells. At early blastula stages, Wnt and BMP signals interact to induce epidermal fate, but when and how cells initially acquire neural plate border fate remains poorly defined. We...

... with bFGF and noggin express Xslu but not NCAM although the mesoderm marker Xbra is also expressed. Explants treated with noggin alone express NCAM only. An indication that induction of the neural plate border is regulated independently of the neural plate is obtained from experiments using ultraviolet...

... in a way that reveals the subdivision of the mesoderm before its derivatives are overtly differentiated. Xsna is also expressed in the ectoderm of the prospective neural fold from stage 11, in a distinct band of cells surrounding the prospective neural plate, which we designate the neural plate border...