... by The Company of Biologists Ltd 2024 Summary: This Spotlight looks at the history of the C. elegans homeobox field, discussing the prevalent role of homeodomain protein expression and function in C. elegans nervous system development. C. elegans Hox Homeobox Neural development Patterning...

... to the accessibility of this model, phagocytosis of migrating neural crest cells could be observed in real time for the first time in a mammalian model. We thus introduce a tractable in vitro model to study some of the key morphogenetic and cell type derivation events during early neural development. * Author...

... Alliance for Research on Schizophrenia & Depression Metabolism Neural development Organoids In vitro models Summary: This Spotlight discusses how findings in intestinal and cancer organoids could be applied to neural organoid models to probe metabolic changes during human...

... and reproduction in any medium provided that the original work is properly attributed. Highlighted Article: The Drosophila CTIP1/2 (Bcl11a/b) homologue chronophage regulates the temporal cascade and neural stem cell competence in the embryonic central nervous system. Temporal patterning Neural...

... neural development. By profiling the genome-wide dynamics of H3K9ac, H3K9cr and H3K18la in combination with ATAC and RNA sequencing, we reveal that these marks are tightly correlated with chromatin state and gene expression, and extensively involved in transcriptome remodeling to promote cell-fate...

... into endogenous E2A recapitulates the neural defects seen in E2A null cells. Despite their widespread expression during embryogenesis ( Pérez-Moreno et al., 2001 ), a definitive role for Class I bHLH TFs in early neural development has not been explored, with E-proteins often relegated to simply being...

.... To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and examined their phenotypes focusing on neural development. Although both mutations affected Hes1 oscillations, the type-1 mutation dampened...

... modulates signalling in order to facilitate the differentiation process. Cadherin FGF Neural development Pluripotent Wnt Mouse There is an increasing appreciation that changes in adhesion and morphology help to regulate cell fate changes ( Gilmour et al., 2017 ). The homotypic adhesion...

... and motor neuron specification . Neuron   40 , 81 - 95 . 10.1016/j.neuron.2003.08.006 Philippidou , P. and Dasen , J. S. ( 2013 ). Hox genes: choreographers in neural development, architects of circuit organization . Neuron   80 , 12 - 34 . 10.1016/j.neuron.2013.09.020...

... work is properly attributed. Summary: RNA interference identifies SoxN and Sox102F as key regulators of the morphological properties of a neuronal type of the fruit fly visual system that computes the direction of motion. Neural development Layer specificity Optic lobe Drosophila...

... are striking ( Camp et al., 2015 ). However, differences are also observed and can be highly informative. Indeed, differences between human and non-human neural development can be explored using pluripotent stem cell-based models to provide insights into brain evolution. This focus on evolutionary differences...

... understanding of the different steps contributing to neural circuit formation is crucial not only for providing insight into neural development but also for a better comprehension of the pathology of neural disorders. Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung...

... be to examine whether fly ato can rescue the mouse Atoh7 retinal defects, as it does for Atoh1 . If the multiplicity of vertebrate proneural genes contributes to the complexity of neural development then this may be revealed by functional differences between proteins. This indeed is sometimes evident...

... or financial interests. 21 7 2017 18 12 2017 © 2018. Published by The Company of Biologists Ltd 2018 Summary: Loss of the Ret receptor tyrosine kinase causes larval feeding defects associated with abnormal axon innervation and defective peristalsis of the midgut. Neural...

... throughout the pancreas. A screen of pancreatic extracellular signals identified factors that stimulated islet cell development. These included semaphorin 3a, a guidance cue in neural development without known functions in the pancreas. In the fetal pancreas, peripheral mesenchymal cells expressed Sema3a...

... 2017 http://www.biologists.com/user-licence-1-1/ Highlighted Article: A non-cell-autonomous mechanism regulates inhibitory neuron synapse formation at the neuromuscular junction. GABA synapse Neural circuit Neural development E/I balance National Institute...

... 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: During Drosophila sensory organ development, G2-phase arrest serves a dual role: it prevents progenitor self-renewal and it synchronizes cell division with developmental signals. Neural development Sensory...

... repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse Sonic hedgehog (Shh) signaling is crucial for the specification of ventral neural progenitor types that give rise to molecularly...

... examines stem cell-based approaches to analysing human brain development, from specification of particular cell types to building neuronal networks. Cerebral cortex Human brain evolution Neural development Neurogenesis Patterning Pluripotent stem cell The mechanisms of human brain...