... a robust expression during jawbone development. Deletion of Piezo1 in neural crest cells causes jawbone malformations in a small but significant number of mice. We further demonstrate that disruption of Piezo1 and Piezo2 in neural crest cells causes more striking defects in jawbone development than any...

...Ezra Lencer; Addison Rains; Erin Binne; Rytis Prekeris; Kristin B. Artinger ABSTRACT The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration...

...Robert N. Kelsh; Karen Camargo Sosa; Saeed Farjami; Vsevolod Makeev; Jonathan H. P. Dawes; Andrea Rocco ABSTRACT Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from...

...Makoto Abe; Timothy C. Cox; Anthony B. Firulli; Stanley M. Kanai; Jacob Dahlka; Kim-Chew Lim; James Douglas Engel; David E. Clouthier ABSTRACT Neural crest cells (NCCs) within the mandibular and maxillary prominences of the first pharyngeal arch are initially competent to respond to signals from...

... seven base pairs of the last Itpr1 exon exhibited ataxia and aniridia, in which the iris lymphatic vessels, sphincter and dilator muscles, corneal endothelium and stroma were disrupted, but the neural crest cells persisted after completion of AES formation. Our analyses revealed that the 218-amino acid...

... precursors into the adrenal primordia, ensuring correct regulation of the autonomic stress response. Adrenal gland Autonomic nervous system Axon guidance Chromaffin cell Neural crest cell Neuropilin Neuroendocrine chromaffin cells of the adrenal medulla produce adrenaline and noradrenaline...

.... Endothelin Craniofacial Neural crest cell Hinge and caps Knockout mouse Development of the vertebrate face requires the coordinated regulation of patterning cues throughout the pharyngeal arches of the developing embryo. Populated by cranial neural crest cells (NCCs) originating in the dorsal...

...Satoru Hayano; Yoshihiro Komatsu; Haichun Pan; Yuji Mishina Bone morphogenetic protein (BMP) signaling plays many roles in skull morphogenesis. We have previously reported that enhanced BMP signaling through the BMP type IA receptor (BMPR1A) in cranial neural crest cells causes craniosynostosis...

... and are constantly refined through both induction of normal signals and inhibition of inappropriate signals. The connective tissue of the tongue arises from cranial neural crest cell-derived ectomesenchyme within the mandibular portion of the first pharyngeal arch and is likely to be impacted by this signaling...

... ) was conditionally deleted in mouse neural crest cells just after their emigration from the neural tube. We previously identified a major defect in gut colonisation by conditional Itgb1 -null enteric neural crest cells(ENCCs) resulting from their impaired migratory abilities and enhanced aggregation properties. Here...

... of the metameric somites, and PNS neurons and glia differentiate from neural crest cells (NCCs) that preferentially migrate into the anterior sclerotome halves. Previous analyses of mice deficient in the class 3 semaphorin (SEMA3)receptors neuropilin (NRP) 1 or 2 raised the possibility that each controlled...

... cone guidance of peripherally projecting nerves. Here we report that loss of NRP1 or NRP2 also impairs sensory neuron positioning in the mouse head, and that this defect is a consequence of inappropriate cranial neural crest cell migration. Specifically, neural crest cells move into the normally crest...

...Amanda J. Barlow; Adam S. Wallace; Nikhil Thapar; Alan J. Burns The enteric nervous system (ENS) is mainly derived from vagal neural crest cells (NCC) that arise at the level of somites 1-7. To understand how the size and composition of the NCC progenitor pool affects ENS development, we reduced...

...Xin Xu; Richard Francis; Chih Jen Wei; Kaari L. Linask; Cecilia W. Lo Connexin 43 knockout (Cx43α1KO) mice have conotruncal heart defects that are associated with a reduction in the abundance of cardiac neural crest cells (CNCs) targeted to the heart. In this study, we show CNCs can respond...

.... * Author for correspondence (e-mail: [email protected] ) 7 6 2004 © 2004. 2004 Mouse Bone Mandible Patterning Neural crest cell Homeobox gene Craniofacial morphogenesis is orchestrated through a specific array of transcription factors, expressed in both spatially...

...Debra L. Ellies; Vicki Church; Philippa Francis-West; Andrew Lumsden ABSTRACT In the avian hindbrain, the loss of premigratory neural crest cells from rhombomeres 3 and 5 (r3, r5) through programmed cell death contributes to the patterning of emigrant crest cells into three discrete streams...

... a detailed study on the expression of collapsin-1 as well as on the distribution of collapsin-1-binding sites in regions where neural crest cell migration occurs. collapsin-1 expression is detected in regions bordering neural crest migration pathways in both the trunk and hindbrain regions and a receptor...

... that there is a high level of its mRNA within the mesenchyme of the branchial arches at E3-E5, in keeping with the direct effect of endothelin-1 (ET-1) on the fate of this region of the embryo. Unlike the endothelin type B (ETB) receptor mRNA, ETA mRNA is not expressed in neural crest cells during emigration from...

... of the gnathostome rostral head. * Author for correspondence (e-mail: [email protected] ) 30 07 1997 © 1997 by Company of Biologists 1997 cephalic mesenchyme neural crest cell cis -acting element Otx2 homeobox pattern formation transgenic analysis pufferfish...