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Keywords: Neural crest
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Journal Articles
Journal: Development
Development dev.199441.
Published: 28 April 2021
... lethality. Here, we showed that kindlin2 is essential for neural crest (NC) formation in Xenopus embryos. Loss-of-function assays performed with kindlin2- specific morpholino antisense oligos (MOs) or clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 techniques...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev193565.
Published: 15 April 2021
... avian retroviruses allowed us to couple gene knockouts with long-term lineage analysis. We demonstrate the application of our newly engineered constructs and viruses by perturbing β-catenin in vitro and Sox10 , Pax6 and Pax7 in the neural crest, retina, and neural tube and segmental plate in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193888.
Published: 26 October 2020
...Manuel Rocha; Anastasia Beiriger; Elaine E. Kushkowski; Tetsuto Miyashita; Noor Singh; Vishruth Venkataraman; Victoria E. Prince ABSTRACT The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational lineage-tracing experiments that showed the restricted...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
...Weiyi Tang; Marianne E. Bronner ABSTRACT Since its discovery 150 years ago, the neural crest has intrigued investigators owing to its remarkable developmental potential and extensive migratory ability. Cell lineage analysis has been an essential tool for exploring neural crest cell fate and...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187997.
Published: 17 July 2020
... KS2 patients, it is not clear whether differences exist in clinical manifestations relative to KS1. We mutated KMT2D in neural crest cells (NCCs) to study cellular and molecular functions in craniofacial development with respect to UTX. Similar to UTX, KMT2D NCC knockout mice demonstrate hypoplasia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev186619.
Published: 13 July 2020
...Wael Noor El-Nachef; Marianne E. Bronner ABSTRACT The enteric nervous system (ENS) is essential for normal gastrointestinal function. Although the embryonic origin of enteric neurons from the neural crest is well established, conflicting evidence exists regarding postnatal enteric neurogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187047.
Published: 13 July 2020
...;tfec mutants possess severe colobomas and our data demonstrate that Mitf activity is required within cranial neural crest cells (cNCCs) during CF closure. In the absence of Mitf function, cNCC migration and localization in the optic cup are perturbed. These data shed light on the cellular mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
... and experimental demonstration of the physiological relevance of such activities are rare. Here, we have used chick neural crest (NC) cells, a highly migratory stem cell population likened to invasive cancer cells, as a model for physiological epithelial-mesenchymal transition (EMT). We demonstrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
... developing optic cup require neural crest. Ultrastructural analysis reveals that basement membrane formation around the developing eye is also dependent on neural crest, but only specifically around the retinal pigment epithelium. Neural crest cells produce the extracellular matrix protein nidogen: impairing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev185231.
Published: 09 January 2020
...Rebecca McLennan; Mary C. McKinney; Jessica M. Teddy; Jason A. Morrison; Jennifer C. Kasemeier-Kulesa; Dennis A. Ridenour; Craig A. Manthe; Rasa Giniunaite; Martin Robinson; Ruth E. Baker; Philip K. Maini; Paul M. Kulesa ABSTRACT Neural crest migration requires cells to move through an environment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev180133.
Published: 16 December 2019
... types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyron mutant embryos carrying a null...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180075.
Published: 12 November 2019
... disrupted intrinsic muscle patterning, with these defects reproduced following global Shh deletion from E10.5 in pCag - CreERTM; Shhflox/flox embryos. SHH responsiveness was diminished in local cranial neural crest cell (CNCC) populations in both mutants, with SHH targeting these cells through the primary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177618.
Published: 23 September 2019
... development Tbx1 Pax9 Neural crest 22q11 deletion syndrome Conotruncal heart malformations, which affect the outflow tract and aortic arch arteries, occur in 30% of all cases of congenital heart defects ( Thom et al., 2006 ). Approximately 20% of foetuses identified with conotruncal defects by...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev175604.
Published: 29 August 2019
...Gustavo A. Gomez; Maneeshi S. Prasad; Man Wong; Rebekah M. Charney; Patrick B. Shelar; Nabjot Sandhu; James O. S. Hackland; Jacqueline C. Hernandez; Alan W. Leung; Martín I. García-Castro ABSTRACT WNT/β-catenin signaling is crucial for neural crest (NC) formation, yet the effects of the magnitude...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev171017.
Published: 11 April 2019
...Estefanía Sánchez-Vásquez; Marianne E. Bronner; Pablo H. Strobl-Mazzulla ABSTRACT miR-203 is a tumor-suppressor microRNA with known functions in cancer metastasis. Here, we explore its normal developmental role in the context of neural crest development. During the epithelial-to-mesenchymal...
Includes: Supplementary data
Journal Articles
In collection:
Advocacy
Journal: Development
Development (2019) 146 (5): dev169821.
Published: 11 March 2019
...Heather C. Etchevers; Elisabeth Dupin; Nicole M. Le Douarin ABSTRACT We review here some of the historical highlights in exploratory studies of the vertebrate embryonic structure known as the neural crest. The study of the molecular properties of the cells that it produces, their migratory...
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167965.
Published: 22 January 2019
...Harinarayana Ankamreddy; Hyehyun Min; Jae Yoon Kim; Xiao Yang; Eui-Sic Cho; Un-Kyung Kim; Jinwoong Bok ABSTRACT Defects in the middle ear ossicles – malleus, incus and stapes – can lead to conductive hearing loss. During development, neural crest cells (NCCs) migrate from the dorsal hindbrain to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev164269.
Published: 21 November 2018
.... Here, we sought to determine the downstream effectors of Ric-8A during the migration of the vertebrate cranial neural crest (NC) cells. We show that the Gα13 knockdown phenocopies the Ric-8A morphant condition, causing actin cytoskeleton alteration, protrusion instability, and a strong reduction in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev166710.
Published: 26 October 2018
... that Fam46a is expressed in the PPE in Xenopus embryos, and Fam46a knockdown induces abnormalities in the eye formation and the body color. At the neurula stage, Fam46a upregulates the expression of PPE genes and inhibits neural crest formation. We also show that Fam46a physically interacts with Smad1...
Includes: Supplementary data