...Yixin Zang; Greg J. Bashaw ABSTRACT The Netrin receptor Dcc and its Drosophila homolog Frazzled play crucial roles in diverse developmental process, including axon guidance. In Drosophila, Fra regulates midline axon guidance through a Netrin-dependent and a Netrin-independent pathway. However, what...

...Samantha A. Russell; Kaitlin M. Laws; Greg J. Bashaw ABSTRACT The Netrin receptor Frazzled/Dcc (Fra in Drosophila ) functions in diverse tissue contexts to regulate cell migration, axon guidance and cell survival. Fra signals in response to Netrin to regulate the cytoskeleton and also acts...

... in opposite directions along the anteroposterior body axis. Several key regulators of Q cell polarization have been identified, including MIG-21, DPY-19/DPY19L1, the netrin receptor UNC-40/DCC, the Fat-like cadherin CDH-4 and CDH-3/Fat, which we describe in this study. How these different transmembrane...

... that unc-52 , nid-1 and genes of the netrin axon guidance signaling cassette share a common pathway to establish the correct number of somatosensory dendrites. Our studies suggest that, in addition to its role in mediating muscle-skin attachment, UNC-52 functions through immunoglobulin domains to establish...

... mechanisms that control the development of a boundary at the CNS surface and prevent CNS neuron emigration from the neural tube. It has previously been shown that a subset of spinal cord commissural axons abnormally invades sensory nerves in Ntn1 hypomorphic embryos and Dcc knockouts. However, whether netrin...

... of differential sensitivity to the conserved Netrin attractants and Slit repellents is insufficient to explain the guidance of all axons at the midline. In the Drosophila embryonic ventral nerve cord, many axons still cross the midline in the absence of the Netrin genes ( NetA and NetB ) or their receptor...

...Zheng Wang; Qiuyi Chi; David R. Sherwood To transmigrate basement membrane, cells must coordinate distinct signaling activities to breach and pass through this dense extracellular matrix barrier. Netrin expression and activity are strongly associated with invasion in developmental and pathological...

... tyrosine kinase (Abl) plays a crucial role in multiple Drosophila axon guidance pathways during development, though the mechanism by which Abl elicits a diverse set of guidance outputs is currently unknown. We identified Abl in a genetic screen for genes that contribute to Netrin-dependent axon guidance...

...Amy H. Lim; Arminda Suli; Karina Yaniv; Brant Weinstein; Dean Y. Li; Chi-Bin Chien The neural and vascular systems share common guidance cues that have direct and independent signaling effects on nerves and endothelial cells. Here, we show that zebrafish Netrin 1a directs Dcc-mediated axon guidance...

...Karen Lai Wing Sun; James P. Correia; Timothy E. Kennedy Netrins are secreted proteins that were first identified as guidance cues, directing cell and axon migration during neural development. Subsequent findings have demonstrated that netrins can influence the formation of multiple tissues...

... influences the development of its associated neuron. As it projects a long dorsally directed cellular extension, the cap cell reorients the dendrite of the v'ch1 neuron and tows its cell body dorsally. Cap cell morphogenesis is regulated by Netrin-A, which is produced by epidermal cells at the destination...

...Christian M. von Hilchen; Irina Hein; Gerhard M. Technau; Benjamin Altenhein Development of the nervous system and establishment of complex neuronal networks require the concerted activity of different signalling events and guidance cues, which include Netrins and their receptors. In Drosophila...

... for the chemotropic guidance cue netrin 1 and its receptor deleted in colorectal carcinoma (Dcc) in the remodeling of oligodendrocyte processes. Postmigratory, premyelinating oligodendrocytes express Dcc but not netrin 1, whereas mature myelinating oligodendrocytes express both. We demonstrate that netrin 1 promotes...

... show that this phenotype is due to ectopic expression of the axon guidance molecule netrin 1(Ntn1), which regulates basal lamina integrity in the fusion plate. Through a series of genetic experiments, we show that mutually antagonistic interactions between Lrig3 and Ntn1 create complementary expression...

...Sutip Navankasattusas; Kevin J. Whitehead; Arminda Suli; Lise K. Sorensen; Amy H. Lim; Jia Zhao; Kye Won Park; Joshua D. Wythe; Kirk R. Thomas; Chi-Bin Chien; Dean Y. Li There is emerging evidence that the canonical neural guidance factor netrin can also direct the growth of blood vessels. We...

...David S. Garbe; Mike O'Donnell; Greg J. Bashaw The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood. Evidence from...

.../netrin-mediated commissural axon guidance. There are three Caenorhabditis elegans PAKs. We find that each C. elegans PAK represents a distinct group previously identified in other species. Here we examine their roles in the postembryonic migration of the P cell neuroblasts and the axon guidance...

... that is predicted to play an important role in multiple Ras-like GTPase signaling pathways. How these molecules function in axon guidance is largely unknown. Here we observed that,in unc-51 and unc-14 mutants, UNC-5, the receptor for axon-guidance protein Netrin/UNC-6, abnormally localized in neuronal cell bodies...

..., respectively, and may mediate interactions between cells within a given layer ( Daniel et al., 1995 ; Radice et al.,1997 ). Interactions between the cell layers, at least in the EB,are provided by the secreted cue netrin 1 ( Ntn1 ), which is expressed by LECs, and binds its receptor neogenin ( Neo1 ), present...

... Morpholino Netrin POC Semaphorin Slit The anterior commissure (AC), post-optic commissure (POC) and the optic chiasm are the first major axon pathways to cross the midline of the vertebrate forebrain during embryonic development. The POC is formed as neurons in the lateral diencephalon...