... of RA in A-P patterning described above. The reintroduction of these hPSC-derived populations into embryonic mouse kidney showed evidence of their contribution to both UB and nephrogenic mesenchyme compartments. Furthermore, by 18 days of culture, cells reorganized to form 3D structures comprising...

... maintenance. Within nephrogenic mesenchyme, expression of the Wt1 transcription factor is essential for mesenchyme survival, whereas Six2 is crucial for self-renewal and is required to suppress the premature differentiation of nephron progenitor cells ( Kobayashi et al., 2008 ; Kreidberg et al., 1993...

... of TGFβsignaling. Using a HoxB7cre transgene expressed in ureteric bud and collecting duct, we find that development of the collecting duct is Smad4 independent. By contrast, removal of Smad4 in nephrogenic mesenchyme using the Bmp7 cre/+ allele leads to disorganization of the nephrogenic mesenchyme and impairment...