1-8 of 8
Keywords: Nephrogenesis
Close
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (10): dev197475.
Published: 25 May 2021
... cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analysis revealed that excess GDNF maintains nephron progenitors and nephrogenesis through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4530–4539.
Published: 15 December 2017
...Eunah Chung; Patrick Deacon; Joo-Seop Park Notch signaling plays important roles during mammalian nephrogenesis. To investigate whether Notch regulates nephron segmentation, we performed Notch loss-of-function and gain-of-function studies in developing nephrons in mice. Contrary to the previous...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3907–3913.
Published: 1 November 2016
...Eunah Chung; Patrick Deacon; Sierra Marable; Juhyun Shin; Joo-Seop Park During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 595–608.
Published: 15 February 2016
... transcriptional regulators Six1 and Six2 play non-overlapping roles in nephron progenitors. Transient Six1 activity prefigures, and is essential for, active nephrogenesis. By contrast, Six2 maintains later progenitor self-renewal from the onset of nephrogenesis. We compared the regulatory actions of Six2 in mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2533–2539.
Published: 1 July 2007
... equally to this work 16 4 2007 © 2007. 2007 Canonical Wnt signaling Nephrogenesis Mesenchymal-to-epithelial transition Tubulogenesis Mouse Maintenance of an appropriate homeostatic balance of water and salt levels,and the removal of nitrogenous waste products of metabolism...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (20): 5019–5029.
Published: 15 October 2003
..., presenilin deficiency in the kidney led to severe nephrogenesis defects and virtually no comma- or S-shaped bodies, or mature glomeruli were formed. We document that the mesenchyme was induced which could further progress to renal vesicles in the PSEN-null kidney, indicating that the presenilins...
Journal Articles
Journal: Development
Development (1991) 113 (1): 193.
Published: 9 January 1991
... further. These results argue that the process of nephrogenesis involves at least two distinct stages which can be blocked by LIF: the effect of the initial induction and the future development of epithelialised aggregates. The ability of LIF to regulate the differentiation of kidney blast cells as well...