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Keywords: Neoplasia
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev200110.
Published: 3 February 2022
... in Notch-driven neoplasia (necessity), but show that the sole overexpression of Pdp1 in combination with NICD is not sufficient for optimal growth as observed in NS tumors, suggesting that the development of NS tumors rely on specific levels of Pdp1, together with the involvement of other transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (24): 6143–6153.
Published: 15 December 2003
... development and neoplasia, we disrupted this gene in mammary epithelium using a Cre-loxP approach. Smad4 is expressed in the mammary gland throughout development; however, its inactivation did not cause abnormal development of the gland during the first three pregnancies. Instead, lack of Smad4 gradually...