... evidence that the nectin-afadin axis is essential for proper palate shelf elevation and fusion. Using this technique, we demonstrate that palatal epithelial conditional loss of afadin ( Afdn ) – an obligate nectin- and actin-binding protein – induces a high penetrance of CP, not observed when Afdn...

... are equipped with hair bundles on their apical surfaces. We previously reported that cell-adhesive nectins regulate the checkerboard-like cellular patterning of HCs and SCs in the mouse auditory epithelium. Nectin-1 and -3 are differentially expressed in normal HCs and SCs, respectively, and in Nectin-3...

... that become restricted to an apical domain, coinciding with lumen formation. Once lumen formation has been initiated, elongation occurs by simultaneous extension and additional de novo lumen generation. We demonstrate that lumen formation and elongation require afadin, a nectin adaptor protein implicated...

... in hair bundle morphology and orientation, cellular organization and junctional nectin localization. We present evidence that Lis1 regulates localized Rac-PAK signaling in embryonic hair cells, probably through microtubule-associated Tiam1, a guanine nucleotide exchange factor for Rac. Lis1 ablation...

... response in post-crossing commissural axons. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 1 12 2009 © 2010. 2010 Axon guidance In ovo RNAi Nectin-like Nectin Midline...

...Maiko Inagaki; Kenji Irie; Hiroyoshi Ishizaki; Miki Tanaka-Okamoto; Koji Morimoto; Eiji Inoue; Toshihisa Ohtsuka; Jun Miyoshi; Yoshimi Takai Nectins are Ca 2+ -independent immunoglobulin-like cell-cell-adhesion molecules consisting of four members. Nectins homophilically and heterophilically trans...