... and whether these effects contribute to neurodegeneration in Niemann–Pick disease type C (NPC). Degeneration of cerebellar Purkinje cells occurs at an earlier stage and to a greater extent in NPC; therefore, we analyzed the effect of NPC1 deficiency on microglia and on climbing fiber synaptic refinement...

... of murine fetal neural progenitor cells towards pluripotency and is reversed in neural differentiation of pluripotent cells. Cell mechanics Pluripotency iPSC NPC Real-time deformability cytometry AFM Somatic cells can regain their pluripotency when forced to express a set of four defined...

...Stefania Senger; John Csokmay; Tanveer Akbar; Takako Iida Jones; Prabuddha Sengupta; Mary A. Lilly The nuclear pore complex (NPC) mediates the transport of macromolecules between the nucleus and cytoplasm. Recent evidence indicates that structural nucleoporins, the building blocks of the NPC, have...