...Yi Arial Zeng; Maryam Rahnama; Simon Wang; Worlanyo Sosu-Sedzorme; Esther M. Verheyen Drosophila Nemo is the founding member of the Nemo-like kinase(Nlk) family of serine/threonine protein kinases that are involved in several Wnt signal transduction pathways. Here we report a novel function...

...Eric Röttinger; Jenifer Croce; Guy Lhomond; Lydia Besnardeau; Christian Gache; Thierry Lepage Studies in Caenorhabditis elegans and vertebrates have established that the MAP kinase-related protein NLK counteracts Wnt signalling by downregulating the transcription factor TCF. Here, we present...

... expression of its own antagonist Nemo. In addition to the findings that NLKs can bind to and phosphorylate TCF and LEF-1 proteins ( Ishitani et al.,2003 ) and thereby decrease the DNA-binding affinity of the TCF/β-catenin complex, a model is emerging that NLKs regulate multiple HMG-box containing proteins...