... ) * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany Competing interests statement The authors declare no competing financial interests. 18 4 2012 © 2012. Neurog2 Ngn2 Purkinje cells Cell cycle Cerebellum Dendrite...

...Christopher Hindley; Fahad Ali; Gary McDowell; Kevin Cheng; Alison Jones; Francois Guillemot; Anna Philpott Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD , while simultaneously controlling progenitor maintenance non...

... that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuronal differentiation. Here, we demonstrate that Ngn2 is phosphorylated on multiple serine-proline sites in response...

...Joanna S. T. Asprer; Bora Lee; Chia-Shan Wu; Tegy Vadakkan; Mary E. Dickinson; Hui-Chen Lu; Soo-Kyung Lee The proneural protein neurogenin 2 (NGN2) is a key transcription factor in regulating both neurogenesis and neuronal radial migration in the embryonic cerebral cortex. However, the co-factors...

... pathway that controls the differentiation of mesDA neurons shows that, in the absence of Otx2, the expression of Lmx1a and Msx1 , and the proneural genes Ngn2 and Mash1 is not activated in Sox2 + mesDA progenitors, which largely fail to differentiate into Nurr1 + mesDA precursors. Furthermore...

... of three other bHLH transcription factors: Ngn1,Ngn2 and Mash1 ( Gowan et al.,2001 ). To examine whether the Zic1 repression is specific to Cath1, or whether repression of bHLH transcription factors is a general mechanism for inhibiting differentiation, we analyzed expression of chick Ngn1 , chick Ngn2...