... elongation and growth cone morphology in cultured sensory neurons in response to NGF. From a mechanistic point of view, our findings reveal that NGF regulates Etv4-dependent gene expression of molecules involved in extracellular matrix (ECM) remodeling. Etv4- null mice were less sensitive to noxious heat...

... smooth muscle cells (VSMCs) associate with large diameter veins during angiogenesis. In vivo and in vitro experiments demonstrate that these cells mediate extension of sympathetic axons via nerve growth factor (NGF). This association enables topological targeting of axons to final targets such as large...

...Vincenzo Coppola; Colleen A. Barrick; Eileen A. Southon; Arkady Celeste; Kathryn Wang; Bei Chen; El-Bdaoui Haddad; Jian Yin; Andre Nussenzweig; Arun Subramaniam; Lino Tessarollo The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions...

... vision. We now show that infusions of NT-4/5 and NGF (nerve growth factor) into visual cortex at the onset and the peak of the critical period accelerated LGN neuron growth. BDNF (brain-derived neurotrophic factor) was ineffective. The effects of neurotrophin on LGN development were clearly dissociated...

... of neurotrophin-deprived neurones. To further examine this assertion in vivo, we have studied two populations of NGF-dependent neurones during the period of naturally occurring neuronal death in mice that lack BAX, NGF or the NGF receptor TrkA, alone and in combination. In the superior cervical ganglion (SCG...

... peripheral and central nervous system, suggesting that TGF-β is an important mediator of ontogenetic neuron death. Previous studies suggested that there are other pro-apoptotic molecules, nerve growth factor (NGF) and brain-derived neurotrophic factor, that induce cell death in the nervous system...

... the neurotrophins and Trk receptors, are expressed during the critical time. We have studied the developing avian retina with respect to the role of nerve growth factor (NGF) in these processes. Our starting point for the work was that NGF and its receptor TrkA are expressed in a partially overlapping pattern...

... affecting postmitotic migratory neurones. Interestingly, the application of exogenous NGF reversed the effects of ganglion cell ablation on ganglion cell death. Because the only source of NGF in the retina is that produced by the stratified ganglion cells, we infer that these differentiated neurones...

...Yasushi Enokido; Sean Wyatt; Alun M. Davies ABSTRACT Previous studies have shown that most neurons in cultures established during the early stages of neurogenesis in the embryonic mouse trigeminal ganglion are supported by BDNF whereas most neurons cultured from older ganglia survive with NGF...

...José MarÍa Frade; Yves-Alain Barde The role of nerve growth factor (NGF) and of the neurotrophin receptor p75 (p75 NTR ) in programmed cell death was investigated in the retina and the spinal cord of mouse embryos. Large numbers of cells express p75 NTR in and along the developing optic nerve...

..., DRG were placed between cryosections of neonatal spinal cord and adult sciatic nerve and cultured for 36 to 48 hours in the presence of various neurotrophins. While DRG cultured in NGF-containing media exhibited neurite growth over both spinal cord and sciatic nerve substrates, in the absence...

...Anna Buj-Bello; Luzia G. P. Pinon; Alun M. Davies ABSTRACT Recent work has shown that the survival of the nerve growth factor (NGF)-dependent trigeminal ganglion neurons of the mouse embryo is promoted by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) during the early stages...

...Susan J. Birren; Liching Lo; David J. Anderson ABSTRACT Sympathetic neurons require NGF for survival, but it is not known when these cells first become dependent on neurotrophic factors. We have examined in vitro mitotically active sympathetic neuroblasts immuno-isolated from different embryonic...

...Vladimir L. Buchman; Alun M. Davies ABSTRACT To investigate if different neurotrophins regulate the survival of neurons at successive developmental stages, we studied the effect of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neu-rotrophin-3 (NT-3) on the survival...

...Sarah Harper; Alun M. Davies ABSTRACT To determine if the initial level of NGF mRNA in developing cutaneous epithelium is correlated with its final innervation density, we measured the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic territories of trigeminal...

...Hermann Rohrer; Magdalena Hofer; Rainer Hellweg; Sigrun Korsching; August D. Stehle; Siawusch Saadat; Hans Thoenen The monoclonal antibody 27/21 directed against mouse nerve growth factor (NGF) interferes in vivo with the survival of sensory dorsal root ganglion (DRG) neurones during...

.... that encoding the Nerve Growth Factor receptor, is strongly activated by the withdrawal of axons, and that this activation is largely independent of cAMP. 09 12 1987 © 1988 by Company of Biologists 1988 myelination Schwann cells gene expression cyclic AMP NGF RNA We thank Drs...

...Brigitte Raynaud; Nicole Faucon-Biguet; Simone Vidal; Jacques Mallet; Michel J. Weber The survival of new-born rat sympathetic neurones in culture was increased in a dose-dependent manner by 7S nerve growth factor (NGF). NGF also increased, in a parallel manner, the specific activities of tyrosine...