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Keywords: NANOG
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Journal Articles
Journal: Development
Development (2019) 146 (12): dev172940.
Published: 03 June 2019
... does not determine the rate of pluripotency exit. FRET ERK Single cell Stem cells Nanog Epigenetic inheritance Mouse embryonic stem cells (ESCs) are derived from the inner cell mass of blastocysts, and can give rise to all cells of the developing embryo ( Evans and Kaufman, 1981...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev147793.
Published: 09 January 2018
...James A. Gagnon; Kamal Obbad; Alexander F. Schier ABSTRACT The role of the zebrafish transcription factor Nanog has been controversial. It has been suggested that Nanog is primarily required for the proper formation of the extra-embryonic yolk syncytial layer (YSL) and only indirectly regulates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155366.
Published: 09 January 2018
...Marina Veil; Melanie Anna Schaechtle; Meijiang Gao; Viola Kirner; Lenka Buryanova; Rachel Grethen; Daria Onichtchouk ABSTRACT Nanog has been implicated in establishment of pluripotency in mammals and in zygotic genome activation in zebrafish. In this study, we characterize the development of MZ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2840–2849.
Published: 15 August 2015
... sets to determine the regulation of developmental gene expression by cell cycle, lineage, motility and environment. We apply this technology to the regulation of the pluripotency gene Nanog in mouse embryonic stem cells. Our data reveal the diversity of cell and population-level interactions with Nanog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2770–2779.
Published: 15 July 2014
...Elsa Abranches; Ana M. V. Guedes; Martin Moravec; Hedia Maamar; Petr Svoboda; Arjun Raj; Domingos Henrique Heterogeneous expression of the transcription factor NANOG has been linked to the existence of various functional states in pluripotent stem cells. This heterogeneity seems to arise from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1001–1010.
Published: 01 March 2014
... conditional genetic deletion. Experiments involving mouse embryos deficient for both maternal and zygotic Oct4 suggest that it is dispensable for zygote formation, early cleavage and activation of Nanog expression. Nanog protein is significantly elevated in the presumptive inner cell mass of Oct4 null embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2288–2298.
Published: 01 July 2012
...Rodrigo Osorno; Anestis Tsakiridis; Frederick Wong; Noemí Cambray; Constantinos Economou; Ronald Wilkie; Guillaume Blin; Paul J. Scotting; Ian Chambers; Valerie Wilson The transcription factors Nanog and Oct4 regulate pluripotency in the pre-implantation epiblast and in derivative embryonic stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4853–4865.
Published: 15 November 2011
... on the homeodomain-containing transcription factor Nanog. Compared with other pluripotency-associated genes, however, Nanog shows relatively low sequence conservation. Here, we investigated whether Nanog orthologs have the capacity to orchestrate establishment of pluripotency in Nanog –/– somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 2973–2980.
Published: 15 September 2010
... is dependent on the expression of Nanog . Pluripotency is conserved in the primitive ectoderm of embryos from mammals and urodele amphibians, and here we report the isolation of a Nanog ortholog from axolotls ( axNanog ). axNanog does not contain a tryptophan repeat domain and is expressed as a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 715–724.
Published: 01 March 2010
...Yojiro Yamanaka; Fredrik Lanner; Janet Rossant Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell mass (ICM) of the E3.5 blastocyst. Recent studies showed that EPI and PE progenitors expressing the lineage-specific transcriptional factors Nanog and Gata6...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 4011–4020.
Published: 01 December 2009
...Shinpei Yamaguchi; Kazuki Kurimoto; Yukihiro Yabuta; Hiroyuki Sasaki; Norio Nakatsuji; Mitinori Saitou; Takashi Tada The pluripotency factor Nanog is expressed in peri-implantation embryos and primordial germ cells (PGCs). Nanog-deficient mouse embryos die soon after implantation. To explore the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1339–1349.
Published: 15 April 2009
... pluripotency factor Nanog in human ESCs and in mouse EpiSCs. Nanog in turn prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade,blocking progression along the endoderm lineage. This negative-feedback loop imposes stasis in neuroectoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (19): 3549–3563.
Published: 01 October 2007
... maintenance of their pluripotency and ability to self-renew has been shown to be governed by the transcription factors Oct4(Pou5f1) and Nanog. Oct4 appears to control cell-fate decisions of ESC in vitro and the choice between embryonic and trophectoderm cell fates in vivo. In non-mammalian vertebrates, the...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1193–1201.
Published: 15 March 2006
... is in contrast to mouse embryonic stem cells(MESCs) where addition of leukemia inhibitory factor (LIF) replaces the need for a feeder layer. Recently, the transcription factor Nanog was suggested to allow LIF and feeder-free growth of MESCs. Here, we show that NANOG overexpression in HESCs enables...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (9): 2093–2102.
Published: 01 May 2005
... trophectoderm (TE) that gives rise to the trophoblast lineage. Commitment to ICM lineage is attributed to the function of the two transcription factors, Oct4 (encoded by Pou5f1 ) and Nanog. However, a positive regulator of TE cell fate has not been described. The T-box protein eomesodermin (Eomes) and the...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (25): 6283–6294.
Published: 22 December 2003
... mesoderm formation. © The Company of Biologists Limited 2003 2003 Microarray Anteroposterior axis Gastrulation Signalling pathways Tdgf1 Nanog * Author for correspondence (e-mail: wbirch@mdc-berlin.de ) 10 9 2003 Tissue and organ development of vertebrates is tightly...
Includes: Supplementary data