... expanding cells committed to a neuronal fate, although the signals that govern this population have remained largely unknown. Here, we show that N-myc mediates the functions of Wnt signaling in promoting neuronal fate commitment and proliferation of neural precursor cells in vitro. Wnt signaling and N-myc...

...Sara Ota; Zi-Qiang Zhou; Doug R. Keene; Paul Knoepfler; Peter J. Hurlin The developing limb serves as a paradigm for studying pattern formation and morphogenetic cell death. Here, we show that conditional deletion of N-Myc(Mycn) in the developing mouse limb leads to uniformly small skeletal...

...Yoshio Wakamatsu; Yuko Watanabe; Harukazu Nakamura; Hisato Kondoh ABSTRACT During neural crest development in avian embryos, transcription factor N-myc is initially expressed in the entire cell population. The expression is then turned off in the period following colonization in ganglion and nerve...

... that the product of the retinoblastoma gene (pRb) may also be involved in this pathway. Previously, we have shown that TGF-β1 inhibits branching morphogenesis and N- myc expression in mouse embryonic lung cultures. The purpose of this study was to determine the role of pRb in the inhibition of branching...

...Rosa Serra; Ron W. Pelton; Harold L. Moses ABSTRACT Lung buds isolated from 11.5 days post coitum mouse embryos survive and undergo branching morphogenesis in culture. This organ culture system was used to examine the role of TGFβ1 and N- myc expression in lung branching morphogenesis. By 24 hours...

...Cecilia B. Moens; Brian R. Stanton; Luis F. Parada; Janet Rossant ABSTRACT Two types of mutant allele, one leaky and one null, have been generated by gene targeting at the N- myc locus in embryonic stem cells and the phenotypes of mice homozygous for these mutations have been described...

...Shoji Sawai; Akihiko Shimono; Yoshio Wakamatsu; Cynthia Palmes; Kazunori Hanaoka; Hisato Kondoh The highest expression of the N -myc gene occurs during embryonic organogenesis in the mouse ontogeny, with the peak of expression around embryonic day 9.5. Homozygous N -myc -deficient mice, produced...

...Laura L. Harris; John C. Talian; Peggy S. Zelenka ABSTRACT The present study uses the polymerase chain reaction and in situ hybridization to examine c- myc and N- myc mRNA in the embryonic chicken lens at 6,10,14 and 19 days of development and compares the pattern of expression obtained...

...Peter D. Vize; Ashley Vaughan; Paul Krieg The N-myc proto-oncogene is expressed in a wide range of tissues during mammalian embryogenesis. This observation, along with the oncogenic capacity of this gene, has led to the suggestion that N-myc plays an important role in early development. However...