...Alexia Vite; Caimei Zhang; Roslyn Yi; Sabrina Emms; Glenn L. Radice ABSTRACT Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. At the same time, the N-cadherin/catenin cell adhesion complex accumulates at the cell termini, creating a specialized type of cell...

... to be essential for NC migration in amphibians and zebrafish by controlling cell polarity in a cell contact-dependent manner. Cell contact during CIL requires the participation of the cell adhesion molecule N-cadherin, which starts to be expressed by NC cells as a consequence of the switch between E- and N...

... interkinetic nuclear migration, but mitosis of retinal progenitors occurs in situ . Rapidly dividing retinal progenitors form neurogenic clusters tightly associated with Alcama/N-cadherin-labeled Müller glial radial processes. Genetic suppression of N-cadherin function interferes with basal migration...

...Ki-Sook Park; Barry M. Gumbiner The development of neural crest cells involves an epithelial-mesenchymal transition (EMT) associated with the restriction of cadherin 6B expression to the pre-migratory neural crest cells (PMNCCs), as well as a loss of N-cadherin expression. We find that cadherin 6B...

... induce some of these changes in NC adhesion and also promote specification of NC-derived pigment cells. Here, we show that the zebrafish transcription factor Ovo1 is a Wnt target gene that controls migration of pigment precursors by regulating the intracellular movements of N-cadherin (Ncad). Ovo1...

... that nectin-2, an immunoglobulin-like cell adhesion molecule, is involved in the neurulation of Xenopus embryos in cooperation with N-cadherin. First, we found that, at the beginning of neurulation, nectin-2 was strongly expressed in the superficial cells of neuroepithelium. The knockdown of nectin -2...

... soaked in PDGFA elicit a directional attractive movement response in mesoderm cells, showing that PDGFA can provide directional information. Surprisingly, however, PDGF signalling is also required for directional movement towards other attractants, such as FGF4. PDGF signalling controls N-cadherin...

... introduced N-cadherin cDNA into the E-cadherin genomic locus. We show that the expression of N-cadherin driven from the E-cadherin locus reflects the expression pattern of endogenous E-cadherin. Heterozygous mice co-expressing E- and N-cadherin are vital and show normal embryonic development. Interestingly...

... investigate the function of two families of molecules that are thought to regulate cell sorting and aggregation. By blocking Eph/ephrins or N-cadherin function, we measure changes in neural crest cell migratory behaviors that lead to alterations in sympathetic ganglia formation using a recently developed...

... of layer selection. We observed that R8, R7 and L1-L5 afferents target to their temporary layers independently,suggesting that afferent-target, but not afferent-afferent, interactions dictate the targeting specificity. N-cadherin is required in the first stage for R7 growth cones to reach and remain...

...Zsolt Lele; Anja Folchert; Miguel Concha; Gerd-Jörg Rauch; Robert Geisler; Frédéric Rosa; Steve W. Wilson; Matthias Hammerschmidt; Laure Bally-Cuif N-cadherin (Ncad) is a classical cadherin that is implicated in several aspects of vertebrate embryonic development, including somitogenesis, heart...

...Yang Luo; M. Celeste Ferreira-Cornwell; H. Scott Baldwin; Igor Kostetskii; Jennifer M. Lenox; Melanie Lieberman; Glenn L. Radice ABSTRACT Cell-cell adhesion mediated by some members of the cadherin family is essential for embryonic survival. The N-cadherin-null embryo dies during mid-gestation...

...-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin . Mol. Cell. Biol . 4 , 37 – 47 . 10.1091/mbc.4.1.37 Geiger , B. and Ayalon , O. ( 1992 ). Cadherins . Annu. Rev. Cell Biol . 8 , 307332 . 10.1146/annurev.cb.08.110192.001515 Gittes , G. K...

...Carmen Cifuentes-Diaz; Marc Nicolet; Danièle Goudou; François Rieger; René Marc Mege ABSTRACT N-cadherin, a member of the Ca 2+ -dependent cell adhesion molecule family plays essential roles in morphogenesis and histogenesis. N-cadherin has been shown in vitro to promote myoblast fusion and neurite...

...Patrick Doherty; Stephen D. Skaper; Stephen E. Moore; Alberta Leon; Frank S. Walsh ABSTRACT Monolayers of control 3T3 fibroblasts and 3T3 cells expressing transfected NCAM or N-cadherin have been used as a culture substratum for rat hippocampal neurons. Both NCAM and N-cadherin are expressed...

...Eileen F. Roark; Nancy E. Paradies; Laura A. Lagunowich; Gerald B. Grunwald Our previous studies of the role of cell adhesion in retinal development have focused on the expression and function of N-cadherin, the predominant calcium dependent intercellular adhesion protein of neural tissues. During...

... it with that of N-cadherin. Inununoblot analysis of various organs of 10.5-day embryos showed that R-cadherin is most abundantly expressed in the retina and brain. Immunostaining of the cervical and thoracic regions of embryos revealed that R- and N-cadherin are expressed in all neural tissues. In the neural tube...

...Toshihiko Fujimori; Seiji Miyatani; Masatoshi Takeichi Xenopus embryos express N-cadherin in a pattern similar to that observed in other species, and cells expressing Xenopus N-cadherin can bind to cells expressing chicken N-cadherin in vitro . To investigate the developmental role of this molecule...